Cyclic amine compounds as CCR5 antagonists

Details Cyclic amine compounds as CCR5 antagonists Cyclic amine compounds as CCR5 antagonists

2008-03-25

2008-03-25

Coleman, Brenda L (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C514S249000, C514S255050, C514S293000, C514S300000, C514S303000, C514S312000, C514S316000, C544S129000, C544S336000, C544S350000, C544S355000, C546S082000, C546S120000, C546S121000, C546S187000, C546S188000, C546S189000, C546S190000

Reexamination Certificate

active

07348324

ABSTRACT:
A compound of formula (I) (wherein R1is a hydrogen atom, a hydrocarbon group which may be substituted, a non-aromatic heterocyclic group which may be substituted, R2is a hydrocarbon group which may be substituted, a non-aromatic heterocyclic group which may be substituted, or R1and R2may combine to each other together with A to form a heterocyclic group which may be substituted; A is N or N+—R5.Y−(R5is a hydrocarbon group; Y−is a counter anion); R3is a cyclic hydrocarbon group which may be substituted or a heterocyclic group which may be substituted; n is 0 or 1; R4is a hydrogen atom, a hydrocarbon group which may be substituted, a heterocyclic group which may be substituted, an alkoxy group which may be substituted, an aryloxy group which may be substituted, or an amino group which may be substituted, E is a divalent aliphatic hydrocarbon group which may be substituted by group(s) other than oxo; G1is a bond, CO or SO2; G2is CO, SO2, NHCO, CONH or OCO; J is methine or a nitrogen atom; and each of Q and R is a bond or a divalent C1-3aliphatic hydrocarbon which may be substituted; provided that J is methine when G2is OCO, that one of Q and R is not a bond when the other is a bond and that each of Q and R is not substituted by oxo group(s) when G1is a bond) or a salt thereof has a potent CCR5 antagonistic activity and can be advantageously used for the treatment or prevention of infectious disease of various HIV in human (e.g. AIDS).

REFERENCES:
patent: 4203988 (1980-05-01), Bolhofer et al.
patent: 6833457 (2004-12-01), Miki et al.
patent: 62-89679 (1987-04-01), None
patent: 94/22861 (1994-10-01), None
patent: 99/04794 (1999-02-01), None
patent: 99/17773 (1999-04-01), None
patent: 99/38514 (1999-08-01), None
Singh, No Vaccine Against HIV Yet-Are We Not Perfectly Equipped?, Aug. 29, 2006, Virology Journal, vol. 3, No. 60, pp. 1-7.
D. Bhuniya et al., “Homochiral Lithium Amides: Enantioselective Deprotonation of Cyclohexene Oxide”, Synth. Commun., vol. 24, No. 3, pp. 375-385, 1994.

Affiliated with

Also associated with

Rating

Cyclic amine compounds as CCR5 antagonists does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Cyclic amine compounds as CCR5 antagonists, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Cyclic amine compounds as CCR5 antagonists will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2813484