Cyanine dyes and synthesis methods thereof

Details Cyanine dyes and synthesis methods thereof Cyanine dyes and synthesis methods thereof

1999-04-19

2000-09-05

Seaman, D. Margaret

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

5142242, 5142305, 514249, 514367, 514375, 514394, 514415, 546181, 548465, 5483044, 548152, 548179, 548217, 544 51, 544105, 544353, A61K 3147, A61K 31425, C07D27916, C07D21504, C07D27760

Patent

active

061143502

ABSTRACT:
A cyanine dye having the formula ##STR1## wherein R.sub.1 -R.sub.8 are each independently selected from a group consisting of hydrogen, C.sub.1 -C.sub.6 alkyl group, and C.sub.0 -C.sub.4 alkyl group having a hydrophilic substituent thereon. R.sub.11 and R.sub.12 are chosen to include a free or protected thiol, amine or hydroxyl substituent capable of reacting with a target molecule through a nucleophilic displacement mechanism. The dye is useful in labeling a variety of target molecules. Processes are described for synthesizing suitable heterocyclic and indole derivatives as precursors for the aforementioned cyanine dyes.

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