Crystallized structure of estrogen related receptor gamma in...

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues

Reexamination Certificate

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C530S358000, C530S402000

Reexamination Certificate



A method for the identification of novel compounds that interact and stabilize the ligand binding domain of estrogen-related receptor gamma (ERRγ), a methodology for producing diffraction quality crystal structures in the presence of antagonist and agonist ligands, including Bisphenol A, and the identification of novel biologically-active compounds that have an effect on the transcriptional-activating activity of ERRγ are disclosed.

patent: 6069239 (2000-05-01), Mathias
patent: 6359116 (2002-03-01), Mathias
patent: 2004/0009558 (2004-01-01), Moras et al.
patent: 2005/0074765 (2005-04-01), Blanchard et al.
patent: WO 03/034028 (2003-04-01), None
patent: WO 03/064468 (2003-08-01), None
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