Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
A method for the identification of novel compounds that interact and stabilize the ligand binding domain of estrogen-related receptor gamma (ERRγ), a methodology for producing diffraction quality crystal structures in the presence of antagonist and agonist ligands, including Bisphenol A, and the identification of novel biologically-active compounds that have an effect on the transcriptional-activating activity of ERRγ are disclosed.
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Abad Marta C.
Askari Hossein B.
Lewandowski Frank A.
Milligan Cynthia M.
Johnson & Johnson Pharmaceutical Research & Developmen
Kamage Andrea Jo
Lee Jae W
Nashed Nashaat T
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