Crystallization and structure of a plant peptide deformylase

Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Hydrolase

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C436S004000

Reexamination Certificate

active

07445923

ABSTRACT:
This invention relates to the crystal structure of a plant peptide deformylase polypeptide and methods of using the structure to design compounds that modulate the activity of the polypeptide.

REFERENCES:
patent: 5985273 (1999-11-01), Reed et al.
patent: 6730634 (2004-05-01), Houtz et al.
patent: 6864080 (2005-03-01), Baldwin et al.
patent: 2004/0088755 (2004-05-01), Houtz et al.
A Hypertext Book of Crystallographic Space Group Diagrams and Tables, Birkbeck College, University of London, 1997-1999, Retrieved from the Internet <URL: http://img.chem.ucl.ac.uk/sgp/mainmenu.htm>.
McPherson et al., Eur. J. Biochem. 189:1-23, 1990.
Kierzek et al., Biophys Chem 91:1-20, 2001.
Branden et al., “Introduction to Protein Structure Second Edition”, Garland Publishing Inc., New York, 1999.
Drenth, “Principles of X-ray Crystallography,” Springer, New York, 1995.
Fieulaine et al., The crystal structure of mitochondrial (Type 1A) peptide deformylase provides clear guidelines for the design of inhibitors specific for the bacterial forms, Journal of Biological Chemistry, published Sep. 28, 2005, vol. 280, No. 51, p. 42315-42624.
Dardel et al., Solution structure of nickel-peptide deformylase, J. Mol. Biol. (1998) 280, 501-513.
Chan et al., Crystal Structure of theEscherichia coliPeptide Deformylase, Biochemistry, 1997, 36, 13904-13909.
Definition of “ligand” Retrieved from the Internet <URL:http://stedmans.com/> on Oct. 29, 2007.
Akers, Alan, “Molecular Biology as Virtual Biology: Limitations of Molecular Biology in Pesticide Discovery”, 1996, pp. 85-91, vol. 46, Pesticide Science, Great Britain.
Braun, et al. Purification and sequencing of cytochrome b from potato reveals methionine cleavage of mitochondrially encoded protein, FEBS Letters 316: 128-132, 1993.
Chen, et a., “Actinonin, a Naturally Occurring Antibacterial Agent, Is a Potent Deformylase Inhibitor”, Biochemistry 2000, vol. 39, pp. 1256-1262, American Cancer Society, Washington, D.C.
Giglione et al., “Identification of eukaryotic peptide deformylases reveals universality of N-terminal protein processing mechanisms”, The EMBO Journal, Sep. 13, 2000, pp. 5916-5929, vol. 19, No. 21, European Molecular Biology Organization, France.
Giglione, et al. “Peptide deformylase as a target for new generation, broad spectrum antimicrobial agents”, Microreview, Molecular Microbiology, 2000, 36(6):1197-1205, Blackwell Science, Ltd., Oxford, England.
Meinnel, T., “Peptide deformylasae of Eukaryotic Protists: A Target for New Antiparasitic Agents?” Parasitology Today 200, pp. 156-168, vol. 16, No. 4 Elsevier Science, Ltd., Oxford, England.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Crystallization and structure of a plant peptide deformylase does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Crystallization and structure of a plant peptide deformylase, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Crystallization and structure of a plant peptide deformylase will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-4043401

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.