Crystalline dihydrochloride of cephalosporin derivative and a me

Details Crystalline dihydrochloride of cephalosporin derivative and a me Crystalline dihydrochloride of cephalosporin derivative and a me

1989-09-28

1990-11-13

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D50136, A61K 31545

Patent

active

049703056

ABSTRACT:
The crystalline dihydrochloride of a specific cephalosporin derivative is stable to heat and retains its antibacterial activity even after storage over long periods at high temperature. The crystalline dihydrochloride can be obtained by removing protective groups from the cephalosporin derivative wherein the amino group and carboxy groups are protected and then crystallizing the cephalosporin derivative from a hydrochloric acid aqueous solution. The crystalline dihydrochloride is useful for pharmaceutical preparations.

REFERENCES:
patent: 4810702 (1989-03-01), Shibahara et al.

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