Crystal structure of antibiotics bound to the 30S ribosome...

Details Crystal structure of antibiotics bound to the 30S ribosome... Crystal structure of antibiotics bound to the 30S ribosome...

2006-07-18

2006-07-18

Brusca, John S. (Department: 1631)

Data processing: measuring, calibrating, or testing

Measurement system in a specific environment

Chemical analysis

C435S004000, C702S019000, C702S022000, C703S011000

Reexamination Certificate

active

07079956

ABSTRACT:
The invention provides high resolution X-ray crystal structures of the 30S ribosome, obtained fromThermus thermophilus30S subunit, having a tetragonal space group P41212 to which are bound an antibiotic selected from the group paromomycin, streptomycin, spectinomycin, tetracycline, pactamycin and hygromycin B. An advantageous feature of the structure is that it diffracts at about 3 Å resolution. The invention also provides a crystal of 30S having the three dimensional atomic coordinates of the 30S ribosome, the coordinates being provided in any one of tables 1 to 4. The data may be used for the rational design and modelling of inhibitors for the 30S ribosome, which have potential use as antibiotics.

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