Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1995-03-07
2000-01-11
Tsang, Cecilia J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514 11, 514270, 930270, 530317, A61K 3800, A61K 3812, C07K 512
Patent
active
06013626&
ABSTRACT:
A cryptophycin compound is provided having the structure: ##STR1## Further provided are methods of producing cryptophycins by total synthesis and methods of using cryptophycins in pharmaceuticals. It is a further object of this invention to use cryptophycins to inhibit the proliferation of mammalian cells. Moreover, methods of using cryptophycins to treat neoplasia is also provided.
REFERENCES:
patent: 4845086 (1989-07-01), Sesin
Smith et al., Cancer Research vol. 54 (Jul. 1994) 3779-84.
Ttimurtulu et al., JACS vol. 116, 4729-37 (1994).
Kubayoshi et al, Chem. Pharm. Bull. vol. 42(16) (Oct. 1994) pp. 2196-98.
Goodman & Gilman, "The Pharmacological Basis of Therapeutics" 6th Ed. (MacMillan Publishing 1980) pp. 1249-1255; 1738-1740.
Barrow Russell A.
Corbett Thomas H.
Golakoti Trimurtulu
Hemscheidt Thomas K.
Liang Jian
Celsa Bennett
Kim Stanley H.
Reiter Stephen E.
The University of Hawaii
Tsang Cecilia J.
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