Crude extracts from Andrographis paniculata

Details Crude extracts from Andrographis paniculata Crude extracts from Andrographis paniculata

2008-03-11

2008-03-11

Hoffman, Susan Coe (Department: 1655)

Drug, bio-affecting and body treating compositions

Plant material or plant extract of undetermined constitution...

Reexamination Certificate

active

11116678

ABSTRACT:
This invention relates to a method of inhibiting TNFα or IL-1β expression with an extract ofAndrographis paniculata.The extract contains andrographolide, 14-deoxy-andrographolide, 14-deoxy-11,12-dehydrogen-andrographolide, and neoandrographolide.

REFERENCES:
patent: 2000034233 (2000-02-01), None
patent: 2001-58969 (2001-03-01), None
patent: 2001058969 (2001-03-01), None
English translation of JP 2000034233 A—2000.
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Panossian, et al., “Effect of andrographolide and Kan Jang—fixed combination of extract SHA-10 and extract SHE-3 -on proliferation of human lymphocytes, production of cytokines and immune activation markers in the whole blood cells culture”, Phytomedicine, 9(7):598-605, 2002, abstract.
See, et al., “Increased tumor necrosis factor alpha (TNF-. alpha.) and natural killer cell (NK) function using an integrative approach in late stage cancers”, Immunological Investigations, 31(2):137-153, 2002, abstract.
Habtemariam, S., “Andrographolide inhibits the tumor necrosis factor-.alpha .-induced upregulation of ICAM-1 expression and endothelial-monocyte adhesion”, Phytotherapy Research, 12(1):37-40, 1998, abstract.
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