Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving fixed or stabilized – nonliving microorganism,...
Patent
1998-07-20
2000-12-05
Naff, David M.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving fixed or stabilized, nonliving microorganism,...
435 11, 435 4052, 435181, 530356, 530402, 530816, G01N 130, C12N 1106, A61K 3817, C07K 100, C07K 1706
Patent
active
061565318
ABSTRACT:
Collagen-containing tissue is cross-linked to provide tissue suitable for use in production of bioprosthetic devices. A cross-linking agent is used having an aliphatic component containing about 8 to 40 carbon atoms and two collagen-reactive groups such as isocyanate, epoxy or n-hydroxysuccinimide. The cross-linking agent may be produced by dimerizing fatty acids, and modifying carboxylic acid group of the fatty acids before or after dimerization to contain collagen-reactive groups. The cross-linked tissue has desirable mechanical and biocompatibility features and a reduced susceptibility to calcification.
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Moore Mark A.
Pathak C. P.
Barrow Kenneth S.
Lyren Philip S.
Naff David M.
Scott Timothy L.
Sulzer Carbomedics Inc.
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