Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Patent
1995-06-05
1998-12-01
Prouty, Rebecca E.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
514 8, 514 12, 536 235, C07K 1447, C12N 1512, A61K 3817
Patent
active
058440801
ABSTRACT:
A Corticotropin Releasing Factor-binding protein (CRF-BP) is isolated and purified sufficient to provide AA sequence data from which the DNA is obtained, which is then used to produce the protein recombinantly. The CRF-BP is useful for modulating the biological activity of CRF, such as reducing the high ACTH levels in mammals caused by excess CRF. The CRF-BP or fragments thereof and/or antibodies to the proteins may be employed in diagnostic assays to determine the levels of CRF, CRF-BP and the ratio of CRF/CRF-BP in a vascular fluid sample. The DNA or subsequence thereof can be used as probes for genetic material in certain assays. The anti-CRF-BP antibodies are also useful to purify the CRF-BP protein and to modulate the biological effect of CRF-BPs proteins.
REFERENCES:
D.P. Behan et al., "Isolation of the Human Plasma Corticotrophin-Releasing Factor-Binding Protein", J. Endocrin. 122(1): 23-31 Jul. 1989.
Behan Dominic P.
Fischer Wolfgang H.
Linton Elizabeth A.
Lowry Philip J.
Potter Ellen
Prouty Rebecca E.
The Salk Institute for Biological Studies
The University of Reading
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