Covalently-modified bacterial polysaccharides, stable covalent c

Details Covalently-modified bacterial polysaccharides, stable covalent c Covalently-modified bacterial polysaccharides, stable covalent c

1987-06-18

1989-11-21

Griffin, Ronald W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

536 551, 530402, A61K 3702, A61K 3902, C07K 1504

Patent

active

048823171

ABSTRACT:
Covalently modified bacterial polysaccharides and proteins; covalent conjugates of such polysaccharides linked by a bigeneric spacer, which permits proof of covalency and facilitates purification of conjugated materials, with immunogenic bacterial membrane or other proteins, which conjugates are useful components of bacterial vaccines; and methods of preparing such polysaccharides, proteins and conjugates and of confirming the covalency of the linkage between polysaccharides and proteins.

REFERENCES:
patent: 4243662 (1981-01-01), Asano et al.
patent: 4695624 (1987-09-01), Marburg et al.
patent: 4696677 (1987-09-01), Colegrove et al.

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