Human mitochondrial membrane protein

Details Human mitochondrial membrane protein Human mitochondrial membrane protein

1997-03-07

1998-12-29

Scheiner, Toni R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 231, 536 2431, 435 691, 4352523, 4353201, C07H 2104, C12N 1563, C12N 121

Patent

active

058544143

ABSTRACT:
The present invention provides a human mitochondrial membrane protein (HuTIM17) and polynucleotides which identify and encode HuTIM17. The invention also provides expression vectors and host cells and a method for producing HuTIM17. The invention also provides for antibodies or antagonists specifically binding HuTIM17, and their use in the prevention and treatment of cancer. The invention also provides diagnostic assays. The invention also provides for the use of HuTIM17 in identifying antifungal and antiprotozoal therapeutics.

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Boemer, U. et al. (Direct Submission), GenBank Sequence Database (Accession X97544), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894. (GI 1770564) 8 Jan. 1997.
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Conboy, J.G. et al. "Processing of pre-ornithine transcarbamylase requires a zinc-dependent protease localized to the mitochondrial matrix." Bioch.Biophys.Res. Commun. (1982) 105:1-7.

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