Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1997-01-15
1999-02-23
Knode, Marian C.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
536 265, 536 268, C07H 2104
Patent
active
058745688
ABSTRACT:
A coupling unit of a (6-4) photoproduct represented by the formula (I): ##STR1## wherein R.sup.1 represents a protective group, R.sup.2 represents a methyl group or a 2-cyanoethyl group, and R.sup.3 represents ##STR2## wherein R.sup.5 represents a methyl group or a 2-cyanoethyl group, and R.sup.6 represents a --N(R')(R") group, a N-morpholino group, a N-pyrrolidinyl group or a 2,2,6,6-tetramethyl-N-piperidyl group where R' and R" each represent a lower alkyl group,
a process for preparing the same, a process for preparing an oligonucleotide containing a (6-4) photoproduct by using the same, and a process for preparing DNA containing a (6-4) photoproduct by using the same are disclosed.
REFERENCES:
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Douki, T.; Voituriez, L.; Cadet, J.: "Characterization of the (6-4) photoproduct of 2'-deoxycytidylyl-(3' .fwdarw.5')-thymidine and of its Dewar valence isomer", Photochem. Photobiol., vol. 53, 1991, pp. 293-297 (Issue No. 3).
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Biomolecular Engineering Research Institute
Crane L. Eric
Knode Marian C.
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