Corpuscles of stannius protein, stanniocalcin

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...

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536 2351, 4353201, 435325, C12N 1512, C12N 1518

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active

058374981

ABSTRACT:
There is disclosed a human Corpuscles of Stannius, stanniocalcin polypeptide and DNA(RNA) encoding such polypeptide. There is also provided a procedure for producing such polypepticle by recombinant techniques and for producing antibodies and antagonist/inhibitors against such polypeptide. Another aspect of the invention provides a combination of the polypeptide of the present invention and a suitable pharmaceutical carrier for providing therapeutic treatment of disease or the inhibition of such polypeptide for therapeutic treatment of disease.

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Haddad, M. et al., Endocrinology, 137 (3):2113-2117, 1996.
Stern, P.H., et al., J. Bone Mineral Res., 6(11):1153-60, 1991.
Butkus, A., et al., Purification and Cloning of a Corpuscles of Stannius Protein From Anguilla australis, Mol. Cell Endocrinol., 54:123-33 (1987), abstract only.
Lafeber, F.P. et al., Identification of hypocalcin (teleocalcin isolated from trout Stannius corpuscles, Gen. Comp. Endocrinol. 69:19-30 (1988), Abstract Only.
Milliken, C.E. et al., Effects of Synthetic peptide Fragments of teleocalcin (hypocaloin) on calcium uptake in juvenile rainbow trout (Salmo gairdneri), Gen. Comp. Endocrinol., 77:416-22 (1990), Abstract Only.
Wagner, G.F. et al., Molecular cloning and cDNA sequence analysis of coho salmon stanniocalcin, Mol. Cell. Endocrinol., 90:7-15 (1992), Abstract Only.

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