Corneal implants and manufacture and use thereof

Prosthesis (i.e. – artificial body members) – parts thereof – or ai – Eye prosthesis – Corneal implant

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623 4, A61F 214

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active

051084287

ABSTRACT:
A corneal prosthesis including an optical element having an optically transparent central portion and an anterior surface capable of supporting a layer of epithelial cells, the optical element being made of optical material having water content between 50% and 90% and a tensile strength greater than 20 kg/cm.sup.2, and a porous outer skirt secured to the periphery of said element, said skirt being sufficiently porous to permit cell ingrowth and tissue attachment. Also disclosed are methods of making, seeding and using corneal implants having epithelial layers thereon and porous implant material of a coherent mass of randomly oriented fibers having an interconnected network of pores.

REFERENCES:
patent: 2714721 (1955-08-01), Stone, Jr.
patent: 4118531 (1978-10-01), Hauser
patent: 4418691 (1983-10-01), Yannas et al.
patent: 4475972 (1984-10-01), Wong
patent: 4485096 (1984-11-01), Bell
patent: 4496349 (1985-01-01), Cosentino
patent: 4528325 (1985-07-01), Ofstead
patent: 4563779 (1986-01-01), Kelman
patent: 4565784 (1986-01-01), Franzblau et al.
patent: 4586929 (1986-05-01), Binder
patent: 4604346 (1986-08-01), Bell et al.
patent: 4618649 (1986-10-01), Ofstead
patent: 4673539 (1987-06-01), Hammer et al.
patent: 4715858 (1987-12-01), Lindstrom
patent: 4772283 (1988-09-01), White
patent: 4865601 (1989-09-01), Caldwell et al.
Beahan, P. et al., "A Study of the Interface between a Fibrous Polyurethane Arterial Prosthesis and Natural Tissue", J. Bio. Mat. Res., 1982, vol. 16, pp. 827-838.
Barber, J. C. et al., "The Acceptance of Vitreous Carbon Alloplastic Material, Proplast, in the Rabbit Eye", Inv. Ophthal. Vis. Sci., 1980, vol. 19, pp. 182-191.
Barnham, J. J. et al., "Keratoprosthesis: a Long-Term Review", British J. of Opthalmology, 1983, vol. 67, pp. 468-474.
Bobyn, J. D. et al., "Effect of Pore Size on the Peel Strength of Attachment of Fibrous Tissue to Porous-Surfaced Implants", J. Biomed. Mat. Res., 1982, vol. 16, pp. 571-584.
Civerchia-Perez, L. et al., "Use of Collagen-Hydroxyethylmethacrylate Hydrogels for Cell Growth", Proc. Natl. Acad. Sci. USA, 1980, vol. 77, No. 4, pp. 2064-2068.
Dohlman et al., "Synthetic Polymers in Corneal Surgery", Arch. Ophthalmology, 1967, vol. 77, pp. 252-257.
Dunn, M. W. et al., "Collagen Membranes in Experimental Corneal Surgery", Ophthalmology Surgery, 1971, vol. 2, pp. 9-11.
Gangjee, T. et al., "Species Related Differences in Percutaneous Wound Healing", Ann. Biomed. Eng., 1985, vol. 13, pp. 451-467.
Gipson, I. K. et al., "Hemidesmosome Formation In Vitro", J. Cell. Biol., 1983, vol. 97, pp. 849-857.
Kresina, T. F. et al., "Isolation and Characterization of Basement Membrane Collagen from Human Placental Tissue: Evidence for the Presence of Two Genetically Distinct Collagen Chains", Biochemistry, 1979, vol. 18, pp. 3089-3097.
Jumblatt, M. M. et al., ".beta.-Adrenegic and Serotonergic Responsiveness of Rabbit Corneal Epithelial Cells in Culture", Inv. Opthal. and Vis. Sci., 1983, vol. 24, pp. 1139-1143.
NIH grant application entitled "Development of Functional Biopolymers for the Eye", submitted by Boston University Medical School to NIH and dated Jan. 22, 1981.
Ofstead, R. F. and Poser, C. J., "Semicrystalline Poly (Vinyl Alcohol) Hydrogels: Synthesis and Characterization", Proc. of the ACS Div. Polym. Mat., 1987, vol. 57, pp. 361-365.
Poser, C. J. and Ofstead R. F., "Semicrystalline Poly (Vinyl Alcohol) Hydrogels: Structure and Properties", Proc. of the ACS Div. Polym. Mat., 1987, vol. 57, pp. 366-370.
Sendele, D. D. et al., "Intracorneal Lens Implantation", Arch. Ophthalmology, 1983, vol. 101, pp. 940-944.
Spector, M. et al., "Characteristics of Tissue Growth into Proplast and Porous Poyethylene Implants in Bone", J. Biomed. Mat. Res., 1979, vol. 13, pp. 677-692.
Sugrue, S. P. et al., "Response of Basal Epithelial Cell Surface and Cytoskeleton to Stabilized Extracellular Matrix Molecules", J. Cell Bio., 1981, vol. 91, pp. 45-54.
Trinkaus-Randall et al., "A Technique for Obtaining Corneal Epithelial Cells", Inv. Ophthal. and Vis. Sci., 1985, vol. 26, pp. 233-237.
Trinkaus-Randall, V. and Gipson, I., "Role of Calcium and Calmodulin in Hemidesomosome Formation In Vitro", J. Cell. Bio., 1984, vol. 98, pp. 1565-1571.
Vandersteenhoven, J. J. et al., "Osteoinduction Within Porous Polysulfone Implants at Extraosseous Sites Using Demineralized Allogenic Bone Matrix", J. Biomed. Mat. Res., 1983, vol. 17, pp. 793-806.
von Recum, A. et al., "Permanent Percutaneous Devices", CRC Crit. Rev. Bioeng., 1981, vol. 11, pp. 37-77.
Yamada, H., (F. G. Evans, ed.), "Strength of Biological Material", (Williams & Wilkins, Baltimore), 1970, pp. 219-247.

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