Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1994-09-08
1996-11-19
Spivack, Phyllis G.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
546 88, A61K 3144, C07D47114
Patent
active
055763260
ABSTRACT:
Copper amino acidate diimine nitrate compounds of the formula [Cu(N--N)(N--O)].sup.+NO.sub.3.sup.-, where (N--N) is a diimine selected from 1,10-phenanthroline or 4,7-dimethyl 1,10-phenanthroline and (N--O) is tyrosine-alaninate, threoninate, tryptophanate, valinate, isoleucinate, cysteinate, diglycinate, phenylalaninate, glycinate, histidinate, serinate, tryosinate, aspartate or alaninate and a process for preparing the compounds in which, while maintaining a pH between 5 and 7, a first aqueous solution of Cu(NO.sub.3).sub.2.5H.sub.2 O, having 30 to 35% by weight of elemental copper, is reacted with a second aqueous solution of the diimine having a ratio of 50 to 55% by weight diimine to solution to form a monodiimine nitrate as an intermediate reaction product having the formula [Cu(N--N)(H.sub.2 O).sub.2 ].sup.+ NO.sub.3.sup.- and then reacting the intermediate product with a third aqueous solution containing 10 to 15% by weight of an amino acid, while keeping an alkaline pH between 7 and 8, with an aqueous ammonical solution to obtain the copper compound.
REFERENCES:
patent: 3282649 (1966-11-01), Bittner
patent: 5107005 (1992-04-01), Azuara
Sone et al., J. Inorg. Nucl. Chem. (31), pp. 117-126, (1969).
Kwik, W. L., 2,9-Dimethyl-1,10-phenanthroline Copper Complexes with some sulfur-containing Amino Acids. Oct. 25, 1983. J. Chem. Soc. Dalton Trans. pp. 2269-2272.
Kwik, W. L. Complexes of (2,2'Bipyridyl) Copper(II) and (1,10-Phenanthroline)(Copper(II) with some Amino Acids. 1980. Org. nucl. chem. vol. 42, pp. 303-313.
Spivack Phyllis G.
Universidad Nacional Autonoma de Mexico (UNAM)
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