Controlled absorption pharmaceutical formulation

Details Controlled absorption pharmaceutical formulation Controlled absorption pharmaceutical formulation

1986-11-12

1989-05-02

Rose, Shep K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Capsules

424461, 424462, 424468, 424469, 424470, A61K 922, A61K 952

Patent

active

048266884

ABSTRACT:
A controlled absorption quinidine formulation for oral administration comprises a pellet having a core of quinidine or a pharmaceutically acceptable salt thereof in association with an organic acid and optionally other excipients, and an outer membrane which permits release of quinidine in an aqueous medium at a controlled rate which is substantially pH independent. The pellet has a dissolution rate in vitro, which when measured in a Basket Assembly according to U.S. Pharmacopoeia XXI at 37.degree. C. and 75 r.p.m. is not more than 15% after one hour of measurement. Not more than 50% of the total quinidine is release after a total of 4 hours of measurement, not more than 80% is released after a total of 8 hours of measurement and not less than 90% release is achieved after a total of 24 hours.

REFERENCES:
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patent: 4572833 (1986-02-01), Pedersen et al.
patent: 4578264 (1986-03-01), Stricker et al.
patent: 4606909 (1986-08-01), Beatgaard et al.
patent: 4713248 (1987-12-01), Kjornaes et al.
patent: 4716041 (1987-12-01), Kjornaes et al.

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