Controlled absorption diltiazem formulations

Details Controlled absorption diltiazem formulations Controlled absorption diltiazem formulations

1988-11-18

1991-03-26

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

424494, 424495, A61K 916, A61K 950

Patent

active

050027760

ABSTRACT:
A controlled absorption diltiazem pellet formulation for oral administration comprises a core of diltiazem or a pharmaceutically acceptable salt thereof in association with an organic acid, and a multi-layer membrane surrounding the core and containing a major proportion of a pharmaceutically acceptable film-forming water insoluble synthetic polymer and optionally a minor proportion of a pharmaceutically acceptable film-forming, water soluble synthetic polymer. The number of layers in the membrane and the ratio of the water soluble to water insoluble polymer, when said water soluble polymer is present, being effective to permit release of diltiazem from the pellet at a rate allowing controlled absorption thereof over not less than a twelve hour period following oral administration. The pellet has a dissolution rate in vitro which when measured in a dissolution apparatus (paddle) according to U.S. Pharmacopoeia XXI in 0.05 M KCl at pH 7.0 results in not more than 35% of the total diltiazem being released after 2 hours of measurement. Not more than 60% of the total diltiazem is released after four hours of measurement and 100% of the diltiazem is released no earlier than after 8 hours of measurement in said apparatus.

REFERENCES:
patent: 4432966 (1984-02-01), Zeitoun et al.
patent: 4496558 (1985-01-01), Demarinis et al.
patent: 4606909 (1986-08-01), Bechgaard et al.
patent: 4666702 (1987-05-01), Junginger
patent: 4684516 (1987-08-01), Bhutani

Affiliated with

Also associated with

Rating

Controlled absorption diltiazem formulations does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Controlled absorption diltiazem formulations, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Controlled absorption diltiazem formulations will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-616205