Conjugates of hydroxyalkyl starch and an active agent

Details Conjugates of hydroxyalkyl starch and an active agent Conjugates of hydroxyalkyl starch and an active agent

2002-03-15

2010-10-19

Jiang, Shaojia Anna (Department: 1623)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C536S111000, C514S060000

Reexamination Certificate

active

07816516

ABSTRACT:
The invention relates to compounds, comprising a conjugate of hydroxyalkyl starch (HAS) and an active agent, whereby the hydroxyalkyl starch is either directly covalently bonded to the active agent, or by means of a linker. The invention further relates to methods for the production of a covalent HAS-active agent conjugate, whereby HAS and an active agent are reacted in a reaction medium, characterised in that the reaction medium is water or a mixture of water and an organic solvent, comprising at least 10 wt. % water.

REFERENCES:
patent: 3191291 (1965-06-01), Maier
patent: 4001200 (1977-01-01), Bonsen et al.
patent: 4001401 (1977-01-01), Bonsen et al.
patent: 4053590 (1977-10-01), Bonsen et al.
patent: 4061736 (1977-12-01), Bonsen et al.
patent: 4064118 (1977-12-01), Wong
patent: 4125492 (1978-11-01), Cuatrecasas et al.
patent: 4179337 (1979-12-01), Davis et al.
patent: 4261973 (1981-04-01), Lee et al.
patent: 4412989 (1983-11-01), Iwashita et al.
patent: 4667016 (1987-05-01), Lai et al.
patent: 4703008 (1987-10-01), Lin
patent: 4766106 (1988-08-01), Katre et al.
patent: 4847325 (1989-07-01), Shadle et al.
patent: 4863964 (1989-09-01), Hedlund et al.
patent: 4900780 (1990-02-01), Cerny
patent: 4904584 (1990-02-01), Shaw
patent: 4925677 (1990-05-01), Feijen
patent: 4952496 (1990-08-01), Studier et al.
patent: 5068321 (1991-11-01), Buysch et al.
patent: 5079337 (1992-01-01), Leonard et al.
patent: 5214132 (1993-05-01), Kuga et al.
patent: 5217998 (1993-06-01), Hedlund et al.
patent: 5218092 (1993-06-01), Sasaki et al.
patent: 5218108 (1993-06-01), Sommermeyer et al.
patent: 5281698 (1994-01-01), Nitecki
patent: 5362853 (1994-11-01), Kuga et al.
patent: 5470843 (1995-11-01), Stahl et al.
patent: 5484903 (1996-01-01), Szablikowski et al.
patent: 5543332 (1996-08-01), Lihme et al.
patent: 5581476 (1996-12-01), Osslund
patent: 5622718 (1997-04-01), Al-Shamkhani et al.
patent: 5723589 (1998-03-01), Miljkovic et al.
patent: 5876980 (1999-03-01), DeFrees et al.
patent: 5952347 (1999-09-01), Arison et al.
patent: 6011008 (2000-01-01), Domb et al.
patent: 6083909 (2000-07-01), Sommermeyer et al.
patent: 6261800 (2001-07-01), Nikolics et al.
patent: 6299881 (2001-10-01), Lees et al.
patent: 6340746 (2002-01-01), Roberts et al.
patent: 6375846 (2002-04-01), Jarrett et al.
patent: 6500930 (2002-12-01), Adamson
patent: 6555660 (2003-04-01), Nissen et al.
patent: 6586398 (2003-07-01), Kinstler et al.
patent: 6596861 (2003-07-01), Moreau
patent: 6875594 (2005-04-01), Muir et al.
patent: 7115576 (2006-10-01), Sommermeyer
patent: 7179617 (2007-02-01), DeFrees et al.
patent: 7285661 (2007-10-01), Sommermeyer et al.
patent: 2004/0043446 (2004-03-01), DeFrees et al.
patent: 2004/0180858 (2004-09-01), Sommermeyer
patent: 2005/0063943 (2005-03-01), Sommermeyer et al.
patent: 2005/0181985 (2005-08-01), Hemberger et al.
patent: 2005/0238723 (2005-10-01), Zander et al.
patent: 2006/0019877 (2006-01-01), Conradt et al.
patent: 2006/0217293 (2006-09-01), Orlando et al.
patent: 2 233 725 (1999-09-01), None
patent: 2233725 (1999-09-01), None
patent: 2 441 442 (2003-09-01), None
patent: 2 478 478 (2004-01-01), None
patent: 2 478 480 (2004-01-01), None
patent: 22 33 977 (1973-02-01), None
patent: 26 16 086 (1977-11-01), None
patent: 26 16 086.1 (1977-11-01), None
patent: 30 29 307 (1982-03-01), None
patent: 30 29 307 (1982-03-01), None
patent: 26 46 854 (1989-05-01), None
patent: 38 36 600 (1990-03-01), None
patent: 279 486 (1990-06-01), None
patent: 41 30 807 (1993-03-01), None
patent: 26 07 706 (1993-05-01), None
patent: 196 28 705 (1998-01-01), None
patent: 198 08 079 (1999-08-01), None
patent: 101 12 825 (2002-02-01), None
patent: 100 41 541 (2002-03-01), None
patent: 101 26 158 (2002-12-01), None
patent: 101 35 694 (2003-02-01), None
patent: 101 29 369 (2003-03-01), None
patent: 101 55 098 (2003-05-01), None
patent: 102 09 821 (2003-09-01), None
patent: 102 17 994 (2003-11-01), None
patent: 102 54 745 (2004-06-01), None
patent: 102 56 558 (2004-09-01), None
patent: 0 019 403 (1980-11-01), None
patent: 0 138 572 (1985-04-01), None
patent: 0 218 825 (1987-04-01), None
patent: 0 243 929 (1987-11-01), None
patent: 0 304 183 (1989-02-01), None
patent: 0 307 827 (1989-03-01), None
patent: 0 315 349 (1989-05-01), None
patent: 0 338 916 (1989-10-01), None
patent: 0 402 724 (1990-06-01), None
patent: 0 138 572 (1990-07-01), None
patent: 0 148 605 (1990-07-01), None
patent: 0 205 564 (1991-05-01), None
patent: 0 428 267 (1991-05-01), None
patent: 0 411 678 (1992-01-01), None
patent: 0 127 839 (1992-07-01), None
patent: 0 331 471 (1992-12-01), None
patent: 0 549 721 (1994-04-01), None
patent: 0 605 963 (1994-07-01), None
patent: 0 609 968 (1994-08-01), None
patent: 0 342 557 (1994-11-01), None
patent: 0 640 619 (1995-03-01), None
patent: 0 646 130 (1995-04-01), None
patent: 0 418 523 (1995-06-01), None
patent: 0 668 351 (1995-08-01), None
patent: 0 809 996 (1996-05-01), None
patent: 1 230 935 (2002-08-01), None
patent: 1 400 533 (2002-09-01), None
patent: 1 398 322 (2003-09-01), None
patent: 1 398 327 (2003-09-01), None
patent: 1 398 328 (2003-09-01), None
patent: 1 424 086 (2004-06-01), None
patent: 1 064 951 (2007-08-01), None
patent: 2 378 094 (1978-08-01), None
patent: 1 419 080 (1975-12-01), None
patent: 1 549 246 (1976-10-01), None
patent: 10-287554 (1998-10-01), None
patent: WO 80/02374 (1980-11-01), None
patent: WO 90/07939 (1990-07-01), None
patent: WO 90/15628 (1990-12-01), None
patent: WO 92/11037 (1992-07-01), None
patent: WO 93/23062 (1993-11-01), None
patent: WO 94/01483 (1994-01-01), None
patent: WO 94/05332 (1994-03-01), None
patent: WO 94/07536 (1994-04-01), None
patent: 94/13697 (1994-06-01), None
patent: WO 94/13697 (1994-06-01), None
patent: WO 94/28024 (1994-12-01), None
patent: WO 94/29370 (1994-12-01), None
patent: WO 95/06058 (1995-03-01), None
patent: WO 95/13090 (1995-05-01), None
patent: WO 96/11953 (1996-04-01), None
patent: WO 96/19242 (1996-06-01), None
patent: WO 96/40662 (1996-12-01), None
patent: WO 96/41813 (1996-12-01), None
patent: WO 97/21452 (1997-06-01), None
patent: WO 97/30148 (1997-08-01), None
patent: WO 97/33552 (1997-09-01), None
patent: WO 97/38727 (1997-10-01), None
patent: WO 97/42225 (1997-11-01), None
patent: 98/01158 (1998-01-01), None
patent: WO 98/01158 (1998-01-01), None
patent: WO 98/08856 (1998-03-01), None
patent: 98/20905 (1998-05-01), None
patent: WO 98/20905 (1998-05-01), None
patent: WO 98/32466 (1998-07-01), None
patent: WO 98/56424 (1998-12-01), None
patent: WO 99/07719 (1999-02-01), None
patent: 99/49897 (1999-10-01), None
patent: WO 99/49897 (1999-10-01), None
patent: WO 00/78355 (2000-12-01), None
patent: WO 01/70272 (2001-09-01), None
patent: WO 01/83522 (2001-11-01), None
patent: WO 01/93862 (2001-12-01), None
patent: WO 02/09766 (2002-02-01), None
patent: WO 02/20033 (2002-03-01), None
patent: WO 02/28841 (2002-04-01), None
patent: WO 02/40057 (2002-05-01), None
patent: WO 02/080979 (2002-10-01), None
patent: WO 03/000738 (2003-01-01), None
patent: WO 03/031464 (2003-04-01), None
patent: WO 03/031581 (2003-04-01), None
patent: WO 03/059246 (2003-07-01), None
patent: WO 03/070772 (2003-08-01), None
patent: WO 03/074087 (2003-09-01), None
patent: WO 03/074088 (2003-09-01), None
patent: WO 2004/009082 (2004-01-01), None
patent: WO 2004/024761 (2004-03-01), None
patent: WO 2004/024776 (2004-03-01), None
patent: WO 2004/024777 (2004-03-01), None
patent: WO 2004/030701 (2004-04-01), None
patent: WO 2004/033651 (2004-04-01), None
patent: WO 2004/050710 (2004-06-01), None
patent: WO 2004/065425 (2004-08-01), None
patent: WO 2005/014024 (2005-02-01), None
patent: WO 2005/014035 (2005-02-01), None
patent: WO 2005/014050 (2005-02-01), None
patent: WO 2005/014655 (2005-02-01), None
patent: WO 2005/074993 (2005-08-01), None
patent: WO 2005/092390 (2005-10-01), None
patent: WO 2006/108052 (2006-10-01), None
Sakai et al., “Synthesis and Physiochemical Characterization of a Series of Hemoglobin-Based Oxygen Carriers”, 2000, Bioconjugate Chemistry, 11, p. 56-64.
Definition of dimethyl sulfoxide, The Merck Index, 2006, Merck & Co., 14th edition

Affiliated with

Also associated with

Rating

Conjugates of hydroxyalkyl starch and an active agent does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Conjugates of hydroxyalkyl starch and an active agent, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Conjugates of hydroxyalkyl starch and an active agent will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4233052