Conditioned cell culture medium compositions and methods of use

Details Conditioned cell culture medium compositions and methods of use Conditioned cell culture medium compositions and methods of use

2006-10-10

2006-10-10

O'Hara, Eileen B. (Department: 1646)

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

C424S198100, C424S423000, C435S070300, C435S069100, C435S325000, C435S391000, C435S395000, C435S408000, C514S001000

Reexamination Certificate

active

07118746

ABSTRACT:
Novel products comprising conditioned cell culture medium compositions and methods of use are described. The conditioned cell medium compositions of the invention may be comprised of any known defined or undefined medium and may be conditioned using any eukaryotic cell type. The medium may be conditioned by stromal cells, parenchymal cells, mesenchymal stem cells, liver reserve cells, neural stem cells, pancreatic stem cells and/or embryonic stem cells. Additionally, the cells may be genetically modified. A three-dimensional tissue construct is preferred. Once the cell medium of the invention is conditioned, it may be used in any state. Physical embodiments of the conditioned medium include, but are not limited to, liquid or solid, frozen, lyophilized or dried into a powder. Additionally, the medium is formulated with a pharmaceutically acceptable carrier as a vehicle for internal administration, applied directly to a food item or product, formulated with a salve or ointment for topical applications, or, for example, made into or added to surgical glue to accelerate healing of sutures following invasive procedures. Also, the medium may be further processed to concentrate or reduce one or more factors or components contained within the medium.

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Futaki Shiroh et al, “Arginine-rich peptides: An abundant source of membrane-permeable peptides having potential as carriers for intracellular protein delivery”, Journal of Biological Chemistry, American Society of Biological Chemists, Baltimore, MD, US, vol. 276, No. 8, Nov. 17, 2000, pp. 5836-5840.

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