Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1989-12-01
1991-07-02
Gerstl, Robert
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514326, 514365, 514423, 544 60, 546208, 546209, 548200, 548201, 548530, 548532, 548539, C07D41706, C07D40306, A61K 31425, A61K 3140
Patent
active
050286048
ABSTRACT:
Novel condensed benzene derivatives having prolyl endopeptidase inhibitory, anti-hypoxic, and anti-amnesic activities are disclosed. The compounds are represented by the following (I), ##STR1## wherein A represents a methylene, ethylene, or propylene group, B represents a methylene or ethylene group, m denotes an integer of 0-5, X and Y, which may be same or different, individually represent a methylene group or sulfur atom, R.sup.1 represents a hydrogen atom, a carboxyl, lower alkyloxycarbonyl, hydroxymethyl, or formyl group, R.sup.2 represents a hydrogen atom, a halogen atom, a lower alkyl, lower alkoxy, nitro, or amino group, R.sup.3 represents a hydrogen atom or a lower alkyl group, and the dotted line may optionally be present. They are useful as a medicine for treating or preventing cerebral circulation disorder, cerebral metabolism disorder, or memory disturbance.
REFERENCES:
patent: 4857537 (1989-08-01), Taka
Chemical Abstracts, No. 92, No. 17, Apr. 28, 1990, p. 564, Abstract No. 146492h, Columbus, Ohio, U.S.; & JP-A-79 138 551 (Sumittomo Chemical Co., Ltd.), 27-10-1979.
Journal of the Chemical Society, Chemical Communications, 1981, pp. 1100-1101, London, GB; R. N. Warrener et al.: "Preparation of (-)-(7R)-7-acetyl-7-hydroxy-4,4-dimethoxy-5,6,7,8-tetrahydronapthalen-1 (4H)-one, a Chiral AB-Synthon for Anthracycline Synthesis", p. 1100, Compounds 7,8.
J. Biochem., vol. 104, No. 4, Oct. 1988, pp. 580-586, Tokyo, JP; D. Tsuru et al.: "Thiazolidine Derivatives as Potent Inhibitors Specific for Prolyl Endopeptidase".
Aotsuka Tomoji
Kato Hisayoshi
Miura Naoyoshi
Morita Hikari
Nakata Naoki
Gerstl Robert
Zeria Pharmaceutical Co. Ltd.
LandOfFree
Condensed benzene derivative does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Condensed benzene derivative, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Condensed benzene derivative will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1247352