Image analysis – Applications – Biomedical applications
Patent
1997-12-01
2000-05-16
Johns, Andrew W.
Image analysis
Applications
Biomedical applications
382153, G06K 900
Patent
active
06064754&
ABSTRACT:
The present invention provides computer-assisted methods and apparatus for identifying, selecting and characterizing biomolecules in a biological sample. A two-dimensional array is generated by separating biomolecules present in a complex mixture. A computer-readable profile is constructed representing the identity and relative abundance of a plurality of biomolecules detected by imaging the two dimensional array. Computer-mediated comparison of profiles from multiple samples permits automated identification of subsets of biomolecules that satisfy pre-ordained criteria. Identified biomolecules can be automatically isolated from the two dimensional array by a robotic device in accordance with computer-generated instructions. A supported gel suitable for electrophoresis is provided that is bonded to a solid support such that the gel has two-dimensional spatial stability and the solid support is substantially non-interfering with respect to detection of a label, such as a fluorescent label, associated with one or more biomolecules in the gel.
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Amess Robert
Bruce James Alexander
Parekh Rajesh Bhikhu
Platt Albert Edward
Prime Sally Barbara
Johns Andrew W.
Oxford Glycosciences (UK) Ltd.
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