Compounds, named the "Leustroducsins", their preparation and the

Details Compounds, named the "Leustroducsins", their preparation and the Compounds, named the "Leustroducsins", their preparation and the

1992-03-25

1994-08-02

Tsang, Cecilia

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Phosphorus containing other than solely as part of an...

549222, A61K 31665, C07F 906

Patent

active

053345878

ABSTRACT:
New compounds, which we have named the "Leustroducsins" have the formula (I): ##STR1## in which R represents a 5-methylhexanoyloxy group, a 6-methyloctanoyloxy group or a 7-methyloctanoyloxy group, and salts thereof, and may be prepared by fermentation using a microorganism of the genus Streptomyces, especially a strain of the species Streptomyces platensis, such as strain SANK 60191 (FERM BP-3288). These compounds may be used for the treatment or prophylaxis of: adverse reactions resulting from cancer chemotherapy or radiotherapy; infections; cancer; cerebral dysfunction; and fungal infections.

REFERENCES:
Br. J. Cancer (1989), 59, "Clinical Significance of the Haemopoietic Growth Factors"; S. Devereux et al; pp. 2-5.
Nippon Acta Radiologica, 48, (4), "Restorative Effect of MDP-Lys (L18) on Leukopenia of Cancer Patient Treated With Radiotherapy"; T. Okawa et al; (1988); pp. 514-522.
Exp. Hematol., 16, "A Burst-promoting Activity Derived from the Human Bone Marrow Stromal Cell Line KM-102 Is Identical to the Granulocyte-Macrophage Colony-Stimulating Factor", T. Kohama et al; (1988); pp. 603-608.
Science, 225, "Turnover of Inositol Phospholipids and Signal Transduction"; Y. Nishizuka; (1984) pp. 1365-1370.
J. Cell Physiol., 91, "Conditions Controlling the Proliferation of Haemopoietic Stem Cells in Vitro", T. M. Dexter et al; (1977)p; pp. 335-344.
Proc. Natl. Acad. Sci. USA, 82, "Generation of Functional Clonal Cell Lines From Human Bone Marrow Stroma", K. Harigaya et al; (1985); pp. 3477-3480.
The Journal of Antibiotics, XLII, "Novel Antitumor Antibiotic Phospholine"; T. Ozasa et al; (1989); pp. 1331-1338.

Affiliated with

Also associated with

Rating

Compounds, named the "Leustroducsins", their preparation and the does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Compounds, named the "Leustroducsins", their preparation and the, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Compounds, named the "Leustroducsins", their preparation and the will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-64950