Compounds from biopolymers and effector substances which are lin

Details Compounds from biopolymers and effector substances which are lin Compounds from biopolymers and effector substances which are lin

1990-07-06

1994-06-14

Springer, David B.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

435 771, 435 79, 5483147, 548468, C07D40306

Patent

active

053211421

ABSTRACT:
The invention relates to compounds from biopolymers and effector substances which are linked with the aid of derivatives of optically active amino acids in which the amino group has been converted into a maleimido group and the carboxyl group into an active ester group.

REFERENCES:
patent: 4868106 (1989-09-01), Ito et al.
Anderson et al., "The Use of Esters of N-Hydroxysuccinimide in Peptide Synthesis", J. Am. Chem. Soc. 86 (1964) pp. 1839-1842.
Ghose et al., "Preparation of Antibody-Linked Cytotoxic Agents", Methods in Enzymology, vol. 93 (1983) pp. 280-333.
Ishikawa et al., "Enzyme Labeling of Antibodies and Their Fragments for Enzyme Immunoassay and Immunohistochemical Staining", Journal of Immunoassay, vol. 4, No. 3 (1983) pp. 209-237.
Keller et al., "Preparation and Some Properties of Maleimido Acids and Maleoyl Derivatives of Peptides", Helvetica Chimica Acta--Vol. 58, No. 2 (1975) pp. 531-541.
Rich et al., "Alkylating Derivatives of Amino Acids and Peptides. Synthesis of N-Maleoylamino Acids, [1-(N-Maleoylglycyl)cysteinyl]oxytocin, and [1-(N-Maleoyl-11-aminoundecanoyl)cysteinyl]oxytocin. Effects on Vasopressin-Stimulated Water Loss from Isolated Toad Bladder.", J. Med. Chem. 18 (1975) pp. 1004-1010.

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