Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2007-07-17
2008-08-05
Stockton, Laura L. (Department: 1626)
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
C514S363000
Reexamination Certificate
active
07408068
ABSTRACT:
The present invention relates to compounds of the Formulawherein R3, R5, R7, U, X, Y and Z are as defined. Compounds of the Formula I have activity inhibiting production of Aβ-peptide. This invention also relates to pharmaceutical compositions and methods of treating diseases, for example, neurodegenerative diseases, e.g., Alzheimer's disease, in a mammal comprising compounds of the Formula I.
REFERENCES:
patent: 6323315 (2001-11-01), Pettit et al.
patent: 7253195 (2007-08-01), Chen
patent: WO2001/81298 (2001-11-01), None
Thompson, et al., “Protein Conformational Misfolding And Amyloid Formation: Characteristics Of A New Class Of Disorders That Include Alzheimer's And Prion Diseases,”Current Medicinal Chemistry, 2002, 1751-1762, vol. 9, No. 19.
Brown, et al., “Drug Therapy In Human And Experimental Transmissible Spongiform Encephalopathy,”Neurology, 2002, 1720-1725, vol. 58, No. 12.
Petit, et al., CA 134:237837, 2001.
Pfizer Inc.
Stockton Laura L.
Tidwell Jeffrey H.
Zielinski Bryan C.
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