Compounds and methods for the modulation of CD154

Details Compounds and methods for the modulation of CD154 Compounds and methods for the modulation of CD154

2007-09-18

2007-09-18

Tsang, Cecilia J. (Department: 1654)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C514S575000

Reexamination Certificate

active

10476237

ABSTRACT:
The present invention relates to compounds that are capable of modulating CD154 mobilization and that are useful for stabilizing the thrombotic process and reducing the activation of cells involved in an inflammatory response. The present invention also relates to methods useful for identifying such compounds. The present invention also relates to the treatment of platelets for transfusion with metalloproteinase inhibitors to treat or prevent inflammation. The present invention also includes compositions and methods to treat injury and disease related to such biological processes.

REFERENCES:
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patent: 5691382 (1997-11-01), Crimmin et al.
patent: 6861504 (2005-03-01), Phillips et al.
Federici et al., The Journal of Clinical Investigation, 2005, vol. 115, No. 12, pp. 3494-3505.
Sommer et al., Neuroscience Letters, 1997, vol. 237, pp. 45-48.
“Integrilin”,Millennium Pharmaceuticals, Inc.Product description.
“Matrix Metalloproteinases (MMPs) Inhibitors of MMPs'.”,Calbiochem. Product description, Cat. Nos. 324385, 364205 and 444274., unknown.
Ondetti, et al., “MMP Inhibitors and TAPI Quick Reference”,Peptide International, Inc.Product description, unknown.

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