Compounds and methods for preparing methanesulfonamides

Details Compounds and methods for preparing methanesulfonamides Compounds and methods for preparing methanesulfonamides

2007-06-19

2007-06-19

O'Sullivan, Peter (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

C549S323000, C549S475000, C560S017000, C564S510000

Reexamination Certificate

active

11068287

ABSTRACT:
A process for preparing (S)-(−)-N-[4-[4-[ethyl(6-fluoro-6-methylheptyl)amino]-1-hydroxy]phenyl]methanesulfonamide hemifumarate salt, which comprises reacting N-[4-[(2S)-tetrahydro-5-hydroxy-2-furanyl]phenyl]methanesulfonamide(IIa) with fluoroamine (III) in the presence of triacetoxyborohydride and ethyl acetate to provide [4-[-4-[ethyl(6-fluoro-6-methylheptyl)amino]-1-hydroxylphenyl]methanesulfonamide (I) and then converting I into the hemifumarate salt Ia. A process for preparing IIa is also claimed as well as intermediates IIa-IId.

REFERENCES:
patent: 5405997 (1995-04-01), Hester et al.

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