Compounds and methods

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai

Reexamination Certificate

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Details

C514S042000, C536S018700

Reexamination Certificate

active

06878690

ABSTRACT:
The present invention provides phosphotetrahydropyran compounds and the use thereof in treating diseases or conditions that are dependent on T-lymphocyte migration, as well as compositions containing said compounds.

REFERENCES:
patent: 5506210 (1996-04-01), Parish et al.
patent: 6294521 (2001-09-01), Cowden
patent: WO 9705883 (1997-02-01), None
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Lemmen et al “FLEXS: A Method for Fast Flexible Ligand Superposition”, Journal of Medicinal Chemistry, 1998, 41, 4502-4520.*
Flanigan, I.L. et al., Magn. Reson. Chem (1995), 33(3), 231-2. “Assignment of the 1H NMR resonances of D-glycerol-D-ido- and D-glycerol-D-alto-octulose mono- and biphosphates”, Structure 6.
Luengo, J.I. et al., Tetrahedron Lett. (1992), 33(46), 6911-14. “Synthesis of C-fucopyranosyl analogs of GDP-L-fucose as inhibitors of fucosyltransferases”, Compound 15.
Detheux, M. et al., Eur. J. Biochem. (1991), 200(2), 553-61, “Effectors of the regulatory protein acting on liver glucokinase: a kinetic investigation”, Figure 7.
Flanigan, I.L. et al., Magn. Reson. Chem (1995), 33(3), 231-2. “Assignment of the 1H NMR resonaces of D-glycerol-D-ido- and D-glycerol-D-alto-octulose mono- and biphosphates”, Structure 6.
Luengo, J.I. et al., Tetrahedron Lett. (1992), 33(46), 6911-14. “Synthesis of C-fucopyranosyl analogs of GDP-L-fucose as inhibitiors of fucosyltransferases”, Compound 15.
Detheux, M. et al., Eur. J. Biochem. (1991), 200(2), 553-61, “Effectors of the regulatory protein acting on liver glucokinase: a kinetic investigation”, Figure 7.
William J. Ray, Jr. et al., “Reaction of the Isosteric Methylenephosphonate Analog of α-D-Glucose 1-Phosphate with Phosphoglucomutase. Induced-Fit Specificity Revisited”, BIOCHEMISTRY (1993), 32(1), 38-47, XP002258518.

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