Compounds

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C544S279000, C544S330000

Reexamination Certificate

active

07629350

ABSTRACT:
Novel substituted 2,4,8-trisubstituted-8H-pyrido[2,3-d]pyrimidin-7-one compounds and compositions for use in therapy as CSBP/p38 kinase inhibitors.

REFERENCES:
patent: 3843663 (1974-10-01), Williams et al.
patent: 4560691 (1985-12-01), Lesher et al.
patent: 4886807 (1989-12-01), Kitamura et al.
patent: 4897395 (1990-01-01), Duch et al.
patent: 5304560 (1994-04-01), Shimazaki et al.
patent: 5409930 (1995-04-01), Spada et al.
patent: 5426110 (1995-06-01), Gossett et al.
patent: 5466692 (1995-11-01), Ellingboe
patent: 5547954 (1996-08-01), Henrie, II et al.
patent: 5597776 (1997-01-01), Bratz et al.
patent: 5620981 (1997-04-01), Blankley et al.
patent: 5733913 (1998-03-01), Blankley et al.
patent: 5733914 (1998-03-01), Blankley et al.
patent: 5760220 (1998-06-01), Giguere et al.
patent: 5767097 (1998-06-01), Tam
patent: 5817670 (1998-10-01), Takayama et al.
patent: 5945422 (1999-08-01), Doherty et al.
patent: 6083948 (2000-07-01), Wilde et al.
patent: 6200977 (2001-03-01), Cushing et al.
patent: 6277989 (2001-08-01), Chakravarty et al.
patent: 6476031 (2002-11-01), Chakravarty et al.
patent: 6479463 (2002-11-01), Wang et al.
patent: 6492520 (2002-12-01), Chen
patent: 6498163 (2002-12-01), Boschelli et al.
patent: 6528508 (2003-03-01), Salituro et al.
patent: 6528513 (2003-03-01), Cusing et al.
patent: 6593333 (2003-07-01), Cumming
patent: 6800626 (2004-10-01), Salituro et al.
patent: 6809199 (2004-10-01), Doherty et al.
patent: 6838559 (2005-01-01), Vaccaro et al.
patent: 7235551 (2007-06-01), Adams et al.
patent: 7314881 (2008-01-01), Adams et al.
patent: 7314934 (2008-01-01), Adams et al.
patent: 7323472 (2008-01-01), Adams et al.
patent: 7423042 (2008-09-01), Boehm et al.
patent: 7479558 (2009-01-01), Boehm et al.
patent: 2003/0114671 (2003-06-01), Chen
patent: 2004/0009993 (2004-01-01), Angiolini et al.
patent: 2004/0063658 (2004-04-01), Roberts et al.
patent: 2004/0142945 (2004-07-01), Barbosa et al.
patent: 2004/0224958 (2004-11-01), Booth et al.
patent: 2004/0235847 (2004-11-01), Quan et al.
patent: 2004/0236084 (2004-11-01), Biwersi et al.
patent: 2004/0242604 (2004-12-01), Bhattacharya et al.
patent: 2005/0187217 (2005-08-01), Wilson et al.
patent: 2005/0272728 (2005-12-01), Altenbach et al.
patent: 2006/0235030 (2006-10-01), Callahan et al.
patent: 2009/0069318 (2009-03-01), Callahan et al.
patent: 0 278 686 (1988-02-01), None
patent: 0 530 994 (1993-03-01), None
patent: 2 123 830 (1984-02-01), None
patent: 1-261306 (1989-10-01), None
patent: 20000038350 (2000-08-01), None
patent: 2004-203751 (2004-07-01), None
patent: WO 92/12154 (1992-07-01), None
patent: WO 94/19350 (1994-09-01), None
patent: WO 95/15952 (1995-06-01), None
patent: WO 95/19774 (1995-07-01), None
patent: WO 95/33750 (1995-12-01), None
patent: WO 97/38992 (1997-10-01), None
patent: WO 98/05661 (1998-02-01), None
patent: WO 98/08846 (1998-03-01), None
patent: WO 98/27098 (1998-06-01), None
patent: WO 98/33798 (1998-08-01), None
patent: WO 99/41253 (1999-08-01), None
patent: WO 99/61444 (1999-12-01), None
patent: WO 99/64400 (1999-12-01), None
patent: WO 00/23444 (2000-04-01), None
patent: WO 00/43374 (2000-07-01), None
patent: WO 01/19828 (2001-03-01), None
patent: WO 01/42243 (2001-06-01), None
patent: WO 01/55147 (2001-08-01), None
patent: WO 01/70741 (2001-09-01), None
patent: WO 02/059083 (2002-08-01), None
patent: WO02/060869 (2002-08-01), None
patent: WO 02/102315 (2002-12-01), None
patent: WO 2004/043367 (2004-05-01), None
patent: WO 05/14558 (2005-02-01), None
Lee J.C. et. al., “A protein kinase involved in the regulation of inflammatory cytokine biosynthesis”, Nature, Dec. 1994, vol. 372, pp. 739-746.
Adams et al., Progress in Medicinal Chemistry, vol. 38, pp. 2-61 (2001).
Armarego, W., Chem. Soc., Quinazolines, Part IV (JCSOA9) p. 561 (1962).
Anderson et al.,J. Org. Chem., 1977, vol. 42, p. 993.
Baker et al.,J. Heterocyclic Chem., 1964, vol. 1, pp. 263-270.
Votta et al., Bone, vol. 15 (5) pp. 533-538 (1994).
Bradlerova et al., Chem. Zvesti, vol. 29 (6), pp. 795-802 (1975).
de Silva et al., J. Chem. Soc., vol. 4, pp. 685-690 (1995).
Engel & Steglich, Liebigs Ann. Chem., p. 1916 (1978).
Ferles et al., Collect. Czech. Chem. Commun., vol. 5 (46), pp. 1167-1172 (1981).
Fischer et al., Rec. Trav. Chim. Pays. Bas., vol. 84, p. 439 (1965).
Fulmer et al., J. Heterocycl. Chem., vol. 17 (4), pp. 799-800 (1980).
Gilbert, E., Synthesis, pp. 30-32 (1972).
Han et al., Science, vol. 265, pp. 808-811 (1994).
Hunter et al., Academic Press, San Diego, vol. 200, p. 3 (1991).
Irwin et al., Archives of Internal Medicine, vol. 157 (17), pp. 1981-1987 (1997).
Ishibashi et al., Chem. Pharm. Bull., vol. 37(8), pp. 2214-2216 (1989).
Johnson et al., PG.A., J.Chem.Soc., Perkin Trans., vol. 1, pp. 895-905 (1996) .
Jurkowska-Kowalczyk, R., Chem., vol. 51 (6), pp. 1191-1199 (1977).
Katritzky et al., Synthesis, pp. 45-47 (Jan. 1993).
Kawasaki et al., J. Bio. Chem., vol. 272(30), pp. 18518-18521 (1997) .
Boehm, et al.,Expert Opinion on Therapeutic Patents, vol. 10(1), pp. 25-37 (2000) .
Carboni et al.,Gazzetta Chimica Italiana, vol. 97(8) pp. 1262-1273 (1967).
Carboni et al.,Gazzetta Chimica Italiana, vol. 98(10) pp. 1174-1188 (1968) .
Ferrarini et al.,Journal of Heterocyclic Chemistry, vol. 21(2) pp. 417-419 (1984) .
Ferrarini et al.,Journal of Heterocyclic Chemistry, vol. 34(5) pp. 1501-1510 (1997) .
Mikailu et al., Zh. Obshch. Khim., vol. 56 (7), pp. 1513-1517 (1986).
Morton et al., Tetrahedron Letters, p. 4123 (1982).
Protecting Groups in Organic Synthesis, 2ndEdition, Greene TW and Wuts PSM, Wiley-Interscience, New York, pp. 10-174 (Hydroxyl and Phenolic) and pp. 309-403 (NH protection) (1991).
Santilli et al., J. Heterocycl Chem., vol. 8, pp. 445-453 (1971).
Snieckus, V., Tetrahedron Letters, vol. 29, p. 2135 (1988).
Stille et al., J. Amer. Chem. Soc., vol. 109, p. 5478 (1978).
Strzybny et al., J. Org. Chem., vol. 28, p. 3381 (1963).
M., Chem. Pharm. Bull., vol. 11, p. 4755 (1985), (Ishikura et. al.).
Thompson et al., J. Org. Chem., vol. 49, p. 5237 (1984).
Uno et al., Bull. Chem. Soc. Japan., vol. 69, pp. 1763-1767 (1996).
Victory et al., Heterocycles, 1985, 23(5), pp. 1135-1141.
Garigipati, R., Tetrahedron Letters, vol. 31, p. 190 (1989).
Kumada et al., Tetrahedron Letters, vol. 22, p. 5319 (1981).
Lamartina et al., Boll. Chim. Farm., vol. 129 (12), pp. 314-316 (1990).
Victory et al., Heterocycles, 1985, 23(8), pp. 1947-1950.
Victory et al., Afinidad, Mar. 1989, vol. 46, pp. 107-113 (Spanish).
Klotzer et al., Monatsh Chem., 1965, vol. 96, p. 1567.
Zavyalov, et al., Khim Farm Zh, vol. 26(3), p. 88 (1992) (With Translation).
Hare, et al.,J. Med Chem., vol. 47 pp. 4731-4740 (2004).
Hunt, et al.,Bioorganic & Medicinal Chemistry Letters, vol. 13 pp. 467-470 (2003).
Nishikawa et al., Chemical Pharm. Bull., 1976, vol. 24(9), pp. 2057-2077.
Foster, et al.,Drug News Perspect., vol. 13(8) pp. 488-497 (2000).
Hanson, G.,Expert Opinion on Therapeutic Patents, vol. 7(7) pp. 729-733 (1997).
Henry, et al.,Bioorganic&Medicinal Chemistry Letters, vol. 8 pp. 3335-3340 (1998).
Herlaar, et al.,Molecular Medicine Today, vol. 5 pp. 439-447 (1999).
Hurlbert, et al.,J. Med. Chem., 1968, vol. 11, pp. 703-707.
Khabar, Khalid,Journal of Interferon&Cytokine Research, vol. 25 pp. 1-10 (2005).
Lee, et al.,Immunopharmacology, vol. 47(2-3) pp. 185-201 (2000).
Marin, et al.,Blood, vol. 98(3) pp. 667-673 (2001).
Marshall,Cell, vol. 80(2) pp. 179-186 (1995).
Seger, et al., FASEB, vol. 9(9) pp. 726-735 (1995).
Lee, et al.,Nature, vol. 372(6508) pp. 739-747 (1994).
Herskowitz,Cell, vol. 80(2) pp. 187-197 (1995).
Cohen,Trends in Cell Biology, vol. 7(9) pp. 353-361 (1997).
Rewcastle, et al.,.Med Chem, vol. 39 pp. 1823-1835 (1996).
Schoffstall,J Org Chem, vol. 36(16) pp. 2385-2387 (1971).
Underwood, et al.,Journal of Pharmacology and Experimental Therapeutics, vol. 293 (1) pp. 281-288 (2000).
Victory, et al.,J Heterocyclic Chem, vol.v 25 pp. 245-247 (1988).
Wadsworth, et al.,Journal of Pharma and Exp Therapeutics, vol. 291(2) pp. 680-687 (1999).
Weinstein, et al.,J. Immunol., vol. 151(7) pp. 3829-3838 (1993).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Compounds does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Compounds, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Compounds will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-4087585

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.