Compound for inhibiting HIV infectivity

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Radical -xh acid – or anhydride – acid halide or salt thereof...

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514576, 514764, 514765, 514766, 562 88, 562 89, A61K 31185, C07C30935, C07C30932

Patent

active

056773439

ABSTRACT:
This invention pertains to the discovery that condensation polymers of an aldehyde and aromatic sulfonic acids and fractions thereof, such as formaldehyde naphthalene-sulfonic acid condensation polymers, can abrogate HIV gp120 binding to CD4, as demonstrated in CD4/gp120 binding assays. In addition to gp120 binding inhibition, the compounds have been shown to inhibit HIV-induced syncytia formation and infectivity of CD+ cells. The use of this compound has been shown to be non-cytotoxic and non-inhibitory to antigen induced T lymphocyte proliferation. Based on these findings, these compounds can be used as a therapeutic agent for the treatment of acquired immunodeficiency syndrome (AIDS), as well as AIDS-related complex (ARC), AIDS-related dementia and non-symptomatic HIV infection. The compounds can also be used to treat blood preparations.

REFERENCES:
patent: 4361547 (1982-11-01), Sipos et al.
patent: 4604404 (1986-08-01), Munson, Jr. et al.
patent: 5177083 (1993-01-01), Rideout et al.
patent: 5308612 (1994-05-01), Lee
Taylor, D.L. et al., "Novel Sulphonic Acid Polymers as Inhibitors of HIV Host-Cell Interactions," Abstract PO-B26-2071, IXth International Conference on Aids. Jun. 1993.
Tan, Ghee T. et al., "Sulfonic acid polymers are potent inhibitors of HIV-1 induced cytopathogenicity and the reverse transcriptases of both HIV-1 and HIV-2," Biochimica et Biophysica Acta, 1181:183-188 1993.
Mohan, Prem et al., "Sufonic acid polymers as a new class of human immunodeficiency virus inhibitors," Antiviral Research 18:139-150 1992.

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