Compositions for inhibiting beta-lactamase

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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C514S201000, C514S202000, C514S208000, C514S209000

Reexamination Certificate

active

06906054

ABSTRACT:
The invention provides pharmaceutical compositions comprising compounds of formula I and IV:wherein R1-R11and A have any of the values defined in the specification, and their pharmaceutically acceptable salts. The pharmaceutical compositions are useful for inhibiting β-lactamase enzymes, for enhancing the activity of β-lactam antibiotics, and for treating β-lactam resistant bacterial infections in a mammal.

REFERENCES:
patent: 4053468 (1977-10-01), Holden
patent: 4150156 (1979-04-01), Beattie et al.
patent: 4356174 (1982-10-01), Barth
patent: 4456755 (1984-06-01), Sheehan et al.
patent: 4459405 (1984-07-01), Hall
patent: 4512999 (1985-04-01), Adam-Molina et al.
patent: 4547371 (1985-10-01), Doherty et al.
patent: 4559157 (1985-12-01), Smith et al.
patent: 4608392 (1986-08-01), Jacquet et al.
patent: 4637999 (1987-01-01), Doherty et al.
patent: 4820508 (1989-04-01), Wortzman
patent: 4826833 (1989-05-01), Chen
patent: 4861768 (1989-08-01), Torii et al.
patent: 4912213 (1990-03-01), Taniguchi et al.
patent: 4938949 (1990-07-01), Borch et al.
patent: 4992478 (1991-02-01), Geria
patent: 4992541 (1991-02-01), Blacklock et al.
patent: 5077286 (1991-12-01), Bissolino et al.
patent: 5126446 (1992-06-01), Brown, Jr. et al.
patent: 5258377 (1993-11-01), Maiti et al.
patent: 5264429 (1993-11-01), Maiti et al.
patent: 5348952 (1994-09-01), Bissolino et al.
patent: 5356888 (1994-10-01), Alpegiani et al.
patent: 5364848 (1994-11-01), Doherty et al.
patent: 5446037 (1995-08-01), Maiti et al.
patent: 5597817 (1997-01-01), Buynak et al.
patent: 5629306 (1997-05-01), Buynak et al.
patent: 5637579 (1997-06-01), Hubschwerlen et al.
patent: 5658567 (1997-08-01), Calhoun et al.
patent: 5681563 (1997-10-01), Buynak et al.
patent: 5760027 (1998-06-01), Buynak et al.
patent: 6156745 (2000-12-01), Buynak et al.
patent: 6303592 (2001-10-01), Buynak et al.
patent: 6391855 (2002-05-01), Blaschuk et al.
patent: 2708219 (1977-09-01), None
patent: 0041047 (1981-12-01), None
patent: 0041768 (1981-12-01), None
patent: 0050805 (1982-05-01), None
patent: 0120613 (1984-10-01), None
patent: 0150984 (1985-08-01), None
patent: 0170192 (1986-02-01), None
patent: 0210065 (1987-01-01), None
patent: 0337704 (1989-10-01), None
patent: 0367606 (1990-05-01), None
patent: 0043546 (1992-01-01), None
patent: 2043639 (1980-10-01), None
patent: 55-136288 (1980-10-01), None
patent: 57-99590 (1982-06-01), None
patent: 58-59990 (1983-04-01), None
patent: 61-109791 (1986-05-01), None
patent: 62-198687 (1987-09-01), None
patent: 64-66189 (1989-03-01), None
patent: 7-82273 (1995-03-01), None
patent: WO-91/09036 (1991-06-01), None
patent: WO-96/17848 (1996-06-01), None
patent: WO-96/17849 (1996-06-01), None
patent: WO-98/24793 (1998-06-01), None
patent: WO-00/63213 (2000-10-01), None
patent: WO-03/020732 (2003-03-01), None
Buynak, John.D. ,et al. ,“7-Alkylidenecephalosporin esters as Inhibitors of Human Leukocyte Elastase”,J. Med. Chem., vol. 40,(1997),pp. 3423-3433.
Applegate, H. E., et al., “7-[2-Hydroxyethyl]Cephalosporanic Acid Derivatives”,Tetrahedron Letters, 19, (1979), pp. 1637-1640.
Chandrasekaran, Srinivasan et al., “Synthesis of Substituted B-Lactams by Addition of Nitromethane to 6-Oxepenicillanates and 7-Oxocephalosporanates”,J. Org. Chem., vol. 42, No. 24,(1977), pp. 3972-3974.
Doherty, James B., et al., “Inhibition of human leukeocyte elastase. 1. Inhibition by C-7-substituted cephalosporin tert-Butyl esters”,J. Med. Chem., 33, (1990), pp. 2513-2521.
Finke, Paul E., et al., “Inhibition of human leukocyte Elastase. 4. Selection of a substituted cephalosporin (L-658,758) as a topical aerosol”,J. Med. Chem., 35, (1992), pp. 3731-3744.
Knight, W. B., et al., “Specificity, stability, and potency of monocyclic B-Lactam inhibitors of human leucocyte elastase”,Biochemistry, 31, (1992), pp. 8160-8170.
Navia, Manuel A., et al., “Crystallographic study of a B-lactam inhibitor complex with elastase at 1.84 A resolution”,Nature, 327, (1987), pp. 79-82.
Shah, Shrenik K., et al., “Inhibition of human leukocyte Elastase. 3. Synthesis and activity of 3'-substituted cephalosporins”,J. Med. Chem., 33, (1990), pp. 2529-2535.
Ursini, F., et al., “New Synthesis of 6-Oxopenicillanates by Ozonolysis of 6-Diazopenicillanates”,Synthesis, 4, (1992), pp. 363-364.
Uyeo, Shoichiro, et al., “Synthesis of (6R, 7R)-Phenylacetylmethyl-3-(1-Methyl-1H-Tetrazol-5-yl)Thiomethyl-1-)xa-1-Dethiacephalosporanic Acid”,Heterocycles, vol. 13,(1979), pp. 255-257.
Abd El-Nabi, H. A., “Novel Heterocycles: A convenient Synthesis of Pyrrolo [2,3-d]pyrazole; Cycloaddition reaction of N-aryl(methyl)pyrrol-2,3-Diones to diazomethane and olefins”,Tetrahedron, 53(5), (Feb. 1997),1813-1822.
Adam, Solange, “Synthesis of Methylene (R)-6-acetonylidene-3-methyl-7-oxo-4-thia-1-azabicyclo [3.2.0] hept-2-ene-carboxylate pivalate”,Heterocycles, 22(7), Columbus, Ohio, U.S.,(1984), 1509-1512.
Arisawa, M., et al., “6-Acetylmethylenepenicillanic Acid (Ro 15-1903), A Potent B-Lactamasae Inhibitor. I. Inhibition of Chromosomally and R-Factor-Mediated B-Lactamases”,The Journal of Antibiotics, 35(11), (Nov. 1982),1578-1583.
Beharry, Zanna, “Penicillin-Derived Inhibitors of the Class A B-Lactamase from Bacillus Anthracis”,ICAAC Poster # C1-679, Chicago, IL, (2003),6 pgs.
Bennett, I. S., et al., “6-(Substituted Methylene)Penems, Potent Broad Spectrum Inhibitors of Bacterial B-Lactamse. V. Chiral 1,2,3-Triazolyl Derivatives”,The Journal of Antibiotics, 44(9), (Sep. 1991),969-978.
Billups, W. E., et al., “Generation of Simple Methylenecyclopropenes as Reactive Intermediates”,Tetrahedron, 37, (1981),3215-3220.
Bitha, P., et al., “6-(1-Hydroxyalkyl)Penam Sulfone Derivatives as Inhibitors of Class A and Class C .beta.-Lactamases I”,Bioorganic & Medicinal Letters, 9(7), (1999),991-996.
Bitha, P., et al., “6-(1-Hydroxyalkyl)Penam Sulfone Derivatives as Inhibitors of Class A and Class C .beta.-Lactamases II”,Bioorganic & Medicinal Chemistry Letters, 9(7), (1999),997-1002.
Black, Jennifer, “Detection of Plasmid-Mediated AmpC B-Lactamases (pAmpCs) in Disk Tests Based on B-Lactamase Inhibitors (BLls) Ro 48-1220 (RO) and LN-2-128 (LN)”,43rd ICAAC Poster #D-258, (2003),6 pgs.
Blacklock, Thomas J., “A Versatile Synthesis of 1,1-Dioxo 7-Substituted Cephems: Preparation of the Human Leukocyte Elastase (HLE) Inhibitor 1,1-Dioxo-trans-7-methoxycephalosporanic Acid tert-Butyl Ester”,J. Org. Chem., 54, (1989),3907-3913.
Brenner, D. G., et al., “6-(Methoxymethylene)penicillanic Acid: Inactivator of RTEM B-Lactamse fromEscherichia coli”,Biochemistry, 23(24), (Nov. 20, 1984),5839-5846.
Buynak, John D., et al., “A Convenient Method for the Production of 6-Oxopenicillinates and 7-Oxocephalosporinates”,Tetrahedron Letters, 39, (1998),4945-4946.
Buynak, John D., et al., “a-Alkylidene B-Lactams. 2. A Formal Synthesis of (+)-Carpetimycin A”,J. Org. Chem., 51, (1986),1571-1574.
Buynak, John D., et al., “Catalytic Approaches to the Synthesis of B-Lactamase Inhibitors”,Tetrahedron, 56, (2000),5709-5718.
Buynak, J. D., et al., “Cephalosporin-Derived Inhibitors of beta-Lactamase. Part 4: The C3 Substituent”,Bioorganic & Medicinal Chemistry Letters, 12, Online Apr. 24, 2002,(2002),1663-1666.
Buynak, J. D., “Coupling Reactions of Cephalosporin Sulfones: A Stable 3-Stannylated Cephem”,Org. Lett. 2001, 3(19), (Aug. 30, 2001),2953-2956.
Buynak, John D., “Penicillin-Derived Inhibitors that Simultaneously Target Both Metallo-and Serine-B-Lactamases”,Bioorganic and Medicinal Chemistry Letters, (Article in Press, available online), (Jan. 22, 2004),6 pgs.
Buynak, John D., et al., “Reactions of (Silylamino)phosphines with Epoxides and Episulfides”,J. Org. Chem., 49, (1984),1828-1830.
Buynak, John D., et al., “Sti

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