Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Patent
1994-04-14
1996-03-05
Nucker, Christine M.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
530395, 530413, 530416, 530828, C07K 102, C07K 118
Patent
active
RE0351717
ABSTRACT:
Compositions useful for detecting ras gene proteins are described consisting of GTP and a protein having an apparent reduced molecular weight of about 115,000-120,000 daltons, or fragments derived therefrom, that stimulate ras protein guanosine triphosphatase activity. Also described are methods whereby the compositions are used to identify cancer therapeutics.
REFERENCES:
patent: 4404188 (1983-09-01), Donahoe et al.
Cales et al., Nature (England), 332 (6164) pp. 548-551, Apr. 7, 1988, "The Cytoplasmic Protein Gap is Implicated as the Target for Regulation by the Ras Gene Product".
Jackson B. Gibbs et al., 1988, PNAS (U.S.A.), 85:5026-5030.
McCormick et al., 1988, Cold Spring Harbor Symposia on Quantitative Biology, LIII:849-854, Cold Spring Harbor Laboratory.
Adari, H., et al., 1988, Science, 240:518-521.
Sigal, Irving S., 1988, Nature, 332:485-486.
McCormick, F. et al., 1988 CSH, (Abstract Only).
Trahey M. et al., (Abstract Only).
Halenbeck Robert F.
Koths Kirston E.
McCormick Francis P.
Trahey Mary M.
Blackburn Robert P.
Cetus Oncology Corporation
Gass David A.
Green Grant D.
Nucker Christine M.
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