Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2009-02-17
2011-11-08
Desai, Rita (Department: 1625)
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
C549S015000, C549S024000, C549S031000, C549S330000, C549S333000, C549S336000, C514S278000, C548S421000
Reexamination Certificate
active
08053576
ABSTRACT:
Spirocyclic cyclohexane compounds corresponding to formula Ia method for producing them, pharmaceutical compositions containing them, and methods of using them.
REFERENCES:
patent: 3328412 (1967-06-01), Atkinson et al.
patent: 3843681 (1974-10-01), Demerson et al.
patent: 4021451 (1977-05-01), Dobson et al.
patent: 4291039 (1981-09-01), Van Dyke, Jr. et al.
patent: 4575508 (1986-03-01), Steiner et al.
patent: 5328905 (1994-07-01), Hamminga et al.
patent: 5631265 (1997-05-01), Audia et al.
patent: 5760051 (1998-06-01), Audia et al.
patent: 5869691 (1999-02-01), Audia et al.
patent: 6586445 (2003-07-01), Thurieau et al.
patent: 7314886 (2008-01-01), Chao et al.
patent: 7332519 (2008-02-01), Hinze et al.
patent: 7446122 (2008-11-01), Chao et al.
patent: 7485634 (2009-02-01), Martin et al.
patent: 7547707 (2009-06-01), Hinze et al.
patent: 7595311 (2009-09-01), Busch et al.
patent: 2004/0038970 (2004-02-01), Thurieau et al.
patent: 2006/0235012 (2006-10-01), Davidson et al.
patent: 2007/0149557 (2007-06-01), Collins et al.
patent: 2008/0280942 (2008-11-01), Diaz-Fernandez et al.
patent: 2009/0042866 (2009-02-01), Lennox et al.
patent: 2009/0326218 (2009-12-01), Martin et al.
patent: 2 226 340 (1973-03-01), None
patent: 0 466 548 (1992-01-01), None
patent: 1 142 587 (2001-10-01), None
patent: 1055203 (1967-01-01), None
patent: WO 99 64420 (1999-12-01), None
German Search Report dated Jul. 14, 2003 w/partial English translation (eight (8) pages).
John P. Mayer, et al., “Application of the Pictet-Splenger Reaction in Combinatorial Chemistry”, Tetrahedron Letters, 1996, pp. 5633-5636, vol. 37, No. 32, Elsevier Science Ltd., printed in Great Britain, PII: S0040-4039(96)01219-1.
T. Nagy, et al., “Synthesis and Analgesic Evaluation of Some 1, 1-Disubstituted 3-Carboxy-4-Phenyl-1, 2, 3, 4-Tetrahydro-β-Carboline Derivatives”, Eur. J. Med. Chem., 1995, pp. 575-586, vol. 30, Elsevier, Paris, France.
International Search Report dated Feb. 23, 2004 w/partial English translation (five (5) pages).
Joerg Berg et al., “Isoenzyme-Specific Cyclooxygenase Inhibitors: A Whole Cell Assay System Using the Human Erythroleukemic Cell Line HEL and the Human Monocytic Cell Line Mono Mac 6”, Journal of Pharmacological and Toxicological Methods 37, vol. No. 4, 179-186 (1997), Elsevier Science Inc., New York.
Fuad A. Abdulla et al., “Axotomy Reduces the Effect of Analgesic Opioids Yet Increases the Effect of Nociceptin on Dorsal Root Ganglion Neurons”, The Journal of Neuroscience, Dec. 1, 1998, 18(23): 9685-9694.
Anthony L. Beck et al., “Synthesis of 3,4-Bridged Indoles by Photocyclisation Reactions. Part 2.1Photocyclisation of Halogenoacetyl Tryptophol Derivatives and α-Chloro Indo1-3-ylalkanoate Esters”, J. Chem. Soc. Perkin Trans. 1, pp. 813-821, 1992.
Girolamo Calo et al., “Pharmacology of nociceptin and Its receptor: a novel therapeutic target”, British Journal of Pharmacology (2000) 129, 1261-1283, Macmillan Publishers Ltd.
E. Campaigne et al., “Benzo[b]thiophene Derivatives. VII. An Abnormal Substitution Product From 3-Chloromethylbenzo[b]thiophene (1)”, Chemistry Laboratories, pp. 231-235, Indiana University, Sep. 1965.
Simon M. N. Efange et al., “Modified Ibogaine Fragments: Synthesis and Preliminary Pharmacological Characterization of 3-Ethy1-5-pheny1-1,2,3,4,5,6-hexahydroazepino[4,5-b]benzothiophenes”, J. Med. Chem. 1998, 41, 4486-4491.
John W. Ellingboe et al., “Antihyperglycemic Activity of Novel Substituted 3H-1,2,3,5-Oxathiadiazole 2-Oxides”, J. Med. Chem. 1992, 35, 1176-1183.
Simon J. Garden et al., “A versatile synthetic methodology for the synthesis of tryptophols”, Tetrahedron 58 (2002) 8399-8412, Pergamon.
L. C. Hendershot et al., “Antagonism of the Frequency of Phenylquinone-Induced Writhing in the Mouse by Weak Analgesics and Nonanalgesics”, vol. 125, pp. 237-240, The Biochemical Research Laboratory, The Dow Chemical Company, Midland, Michigan, Received for publication Sep. 19, 1958.
Francois Jenck et al., “Orphanin FQ acts as an anxiolytic to attenuate behavioral responses to stress”, Proc. Natl. Acad. Sci. USA, vol. 94, pp. 14854-14858, Dec. 1997, Neurobiology.
I. Jirkovsky et al., “Synthesis of 1,3,4,9-Tetrahydro-1-alkylthiopyrano [3,4-b] indole-1-acetic Acids. The Sulfur Isoster of Prodolic Acid”, vol. 12, pp. 937-940, Ayerst Research Laboratories, Montreal, Quebec, Canada, Oct. 1975.
Michael A. King et al., “Spinal analgesic activity of orphanin FQ
ociceptin and its fragments”Neuroscience Letters 223 (1997) 113-116, Elsevier Science Letters.
Daniel Lednicer et al., “4-Amino-4-arylcyclohexanones and Their Derivatives, a Novel Class of Analgesics. 1. Modification of the Aryl Ring”, The Upjohn Company, Research Laboratories, Kalamazoo, Michigan, Received Aug. 7, 1979.
Toshiya Manabe et al., “Facilitation of long-term potentiation and memory in mice lacking nociceptin receptors”, Letters to Nature, vol. 394, pp. 577-581, Aug. 6, 1998, Macmillan Publishers Ltd.
Jean-Claude Meunier et al., “Isolation and structure of the endogenous agonist of opioid receptor-like ORL1receptor” Letters of Nature, vol. 377, pp. 532-535, Oct. 12, 1995.
J. S. Mogil et al., “Orphanin FQ is a Functional Anti-Opioid Peptide”, Letter to Neuroscience, Neuroscience vol. 75, No. 2, pp. 333-337, 1996, Elsevier Science Ltd., Pergamon, Great Britain.
Miyuki Nishi et al., “Unrestrained nociceptive response and disregulation of hearing ability in mice lacking the nociceptin/orphaninFQ receptor”, The EMBO Journal, vol. 16, No. 8, pp. 1858-1864, 1997, Oxford University Press.
James R. Pearson et al., “Vinylindenes and Some Heteroanalogues in the Diels-Alder Reaction. IX* 3-Vinylbenzofuran and 1,4-Naphthoquinone”, Aust. J. Chem., 1991, 44, 907-917.
Rainer K. Reinscheid et al., “Orphanin FQ: A Neuropeptide That Activates an Opioidlike G Protein-Coupled Receptor”, Science, vol. 270, pp. 792-794, Nov. 3, 1995.
Shuichi Yokohama et al., “Synthesis and Antiallergy Activity of [1,3,4] Thiadiazolo[3,2-a]-1,2,3-triazolo[4,5-d] pyrimidin-9(3H)-one Derivatives. II.1,2)6-Alkyl- and 6-Cycloalkylalkyl Derivatives”, Chem. Pharm. Bull., Vo. 40, No. 9, pp. 2391-2398, Sep. 1992.
Donald Zaragoza, “Side Reactions in Organic Synthesis”, (preface and pp. 8 and 9) 2005.
Chang et al., Molecular Pharmacology, 26, 484-488, 1984.
Erchegyi at al., Journal of Medicinal Chemistry 2003, 46, 5587-5596.
Bignan et al., Bioorganic & Medicinal Chemistry Letters 2005, 15, 5022-5026.
Aulenbacher Otto
Englberger Werner
Friderichs Elmar
Henkel Birgitta
Hinze Claudia
Crowell & Moring LLP
Desai Rita
Gruenenthal GmbH
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