Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Particulate form
Patent
1995-02-01
1997-04-15
Page, Thurman K.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Particulate form
424484, 424489, 424490, 424486, 424499, 5147723, A61K 914, A61K 918, A61K 4748, A61K 3800
Patent
active
056207085
ABSTRACT:
Compositions and methods for the oral administration of drugs and other active agents are provided. The compositions comprise an active agent carrier particle attached to a binding moiety which binds specifically to a target molecule present on the surface of a mammalian enterocyte. The binding moiety binds to the target molecule with a binding affinity or avidity sufficient to initiate endocytosis or phagocytosis of the particulate active agent carrier so that the carrier will be absorbed by the enterocyte. The active agent will then be released from the carrier to the host's systemic circulation. In this way, degradation of degradation-sensitive drugs, such as polypeptides, in the intestines can be avoided while absorption of proteins and polypeptides from the intestinal tract is increased.
REFERENCES:
patent: 3845770 (1974-11-01), Theeuwes et al.
patent: 3995631 (1976-12-01), Higuchi et al.
patent: 4034756 (1977-07-01), Higuchi et al.
patent: 4111202 (1978-09-01), Theeuwes
patent: 4320759 (1982-03-01), Theeuwes
patent: 4449983 (1984-05-01), Cortese et al.
patent: 4925678 (1990-05-01), Ranney
patent: 5320824 (1994-06-01), Brodack et al.
Heller, J., "Controlled Release of Biologically Active Compounds From Bioerodible Polymers", Biomaterials, Jan. 1980 1 (1) pp. 51-57.
Sidman, K.R., et al., Journal of Membrane Science 7 (1980) vol. 1, pp. 277-291, "Biodegradable Implantable Sustained Release systems Based on Glutamic Acid Copolymers".
Michel, et al., J. Pharm. Pharmacol., 1991, 43:1-5, "The Effect of Site of Administration in the Gastrointestinal Tract on the Absorption of Insulin from Nanocapsules in Diabetic Rats".
Damge, et al., Diabetes, vol. 37, pp. 246-251 (1988), "New Approach for Oral Administration of Insulin with Polyalkylcyanoacrylate Nano capsules as Drug Carrier".
Dougan, et al., Biochemical Society Transactions, vol. 18, pp. 746-748, (1990), "Bacterial pathogens--a route to oral drug delivery".
Ruoslahti, et al., Science, vol. 238, pp. 491-497 (1987), "New Perspectives in Cell Adhesion: RGD and Integrins".
Mueller, et al., The Journal of Cell Biology, vol. 109, pp. 3455-3464 (1989), "Dynamic Cytoskeleton-Integrin Associations Induced by Cell Binding to Immobilized Fibronectin".
Isberg, Molecular Microbiology, (1989) 3(10), 1449-1453, "Mammalian Cell Adhesion Functions and Cellular Penetration of Enteropathogenic Yersinia Species".
Isberg, Mol. Biol. Med., 7:73-82 (1990), "Pathways for the Penetration of Enteroinvasive Yersinia into Mammalian Cells".
Isberg, Ralph R. and Leong, John M., Cell 60:861-871 (1990), "Invasin, a Protein that Promotes Bacterial Penetration into Mammalian Cells".
Leong, et al., Infection and Immunity, vol. 59, No. 10, pp. 3424-3433 (1991), "Mapping and Topographic Localization of Epitopes of the Yersinia pseudotuberculosis Invasin Protein".
McKeown, et al., Cell Tissue Res., (1990), pp. 523-530, "Role of the Cellular Attachment Domain of Fibronectin in the Phagocytosis of Beads by Human Gingival Fibroplasts in vitro".
Berger et al., Cancer Research, (1988) vol. 48, pp. 1238-1243, "Correlation of c-erb.beta.-2 Gene Amplification and Protein Expression in Human Breast Carcinoma with Nodal Status and Nuclear Grading".
Al Khouri et al., International Journal of Pharmaceutics, vol. 28 (1986) pp. 125-132, "Development of a New Process for the Manufacture of Polyisobutylcyanoacrylate Nanocapsules".
Damage et al., Journal of Controlled Release vol. 13 (1990) pp. 233-239, "Nanocapsules as Carriers for Oral Peptide Delivery".
Amkraut Alfred A.
Yang Heechung
ALZA Corporation
Cagan Felissa H.
Page Thurman K.
Rafa Michael J.
Spear James M.
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