Compositions and methods for the inhibition of phagocytes

Details Compositions and methods for the inhibition of phagocytes Compositions and methods for the inhibition of phagocytes

1996-03-20

1999-01-19

Davenport, Avis M.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

530324, 530325, 530326, 530327, 530328, 530329, 530330, A61K 3800, C07K 200, C07K 400, C07K 500

Patent

active

058614753

ABSTRACT:
The present invention relates to the identification, purification and characterization of novel factors which inhibit phagocyte activation, such as inhibiting polymorphonuclear neutrophil chemotaxis, degranulation and superoxide production. Disclosed are natural peptides purified from the bronchial environment and a variety synthetic peptides and analogues designed to have enhanced or longer-lasting phagocyte-inhibiting activity. The peptides and compositions of the present invention are contemplated for use in modulating inflammatory responses in a number of clinical settings, such as in the treatment of asthma, bronchitis, acute lung injury, rheumatoid arthritis, psoriasis, dermatitis and inflammatory bowel disease, and for use as anti-proliferative agents such as in the treatment of cancer.

REFERENCES:
Kalmokoff et al., Biochem. & Biophys. Res. Comm., vol. 167, No. 1, 1990, pp. 154-160.

Affiliated with

Also associated with

Rating

Compositions and methods for the inhibition of phagocytes does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Compositions and methods for the inhibition of phagocytes, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Compositions and methods for the inhibition of phagocytes will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1247459