Compositions and methods for regulating bacterial pathogenesis

Chemistry: molecular biology and microbiology – Process of mutation – cell fusion – or genetic modification – Introduction of a polynucleotide molecule into or...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C435S252300, C435S007320, C422S067000, C424S093200

Reexamination Certificate

active

07323340

ABSTRACT:
The production of a purified extracellular bacterial signal called autoinducer-2 is regulated by changes in environmental conditions associated with a shift from a free-living existence to a colonizing or pathogenic existence in a host organism. Autoinducer-2 stimulates LuxQ luminescence genes, and is believed also to stimulate a variety of pathogenesis related genes in the bacterial species that produce it. A new class of bacterial genes is involved in the biosynthesis of autoinducer-2.

REFERENCES:
patent: 4107121 (1978-08-01), Stoy
patent: 4692417 (1987-09-01), Webster
patent: 4861709 (1989-08-01), Ulitzur et al.
patent: 4895566 (1990-01-01), Lee
patent: 4917686 (1990-04-01), Bayston et al.
patent: 4952419 (1990-08-01), De Leon et al.
patent: 5103306 (1992-04-01), Weiman et al.
patent: 5166057 (1992-11-01), Palese et al.
patent: 5196318 (1993-03-01), Baldwin et al.
patent: 5593827 (1997-01-01), Bycroft et al.
patent: 5612184 (1997-03-01), Rosson
patent: 5637113 (1997-06-01), Tartaglia et al.
patent: 5658748 (1997-08-01), Mayra-Makinen et al.
patent: 5759798 (1998-06-01), Dunlap
patent: 5788979 (1998-08-01), Alt et al.
patent: 5902283 (1999-05-01), Darouiche et al.
patent: 5925552 (1999-07-01), Keogh et al.
patent: 6017722 (2000-01-01), Becvar et al.
patent: 6020121 (2000-02-01), Bao
patent: 6057288 (2000-05-01), Pearson
patent: 6117485 (2000-09-01), Woodhall et al.
patent: 6197591 (2001-03-01), Stutzman-Engwall et al.
patent: 6218157 (2001-04-01), Kimoto et al.
patent: 6395282 (2002-05-01), Kende et al.
patent: 6537558 (2003-03-01), Kaniga
patent: 6559176 (2003-05-01), Bassler et al.
patent: 6864067 (2005-03-01), Bassler et al.
patent: 2003/0054512 (2003-03-01), Cronan et al.
patent: 2003/0165932 (2003-09-01), Taga et al.
patent: 2005/0227345 (2005-10-01), Whiteley et al.
patent: WO 98/13328 (1998-04-01), None
patent: WO 98/40346 (1998-09-01), None
patent: WO 98/58075 (1998-12-01), None
patent: WO 99/00349 (1999-01-01), None
patent: WO 99/01119 (1999-01-01), None
patent: WO 99/29647 (1999-06-01), None
patent: WO 99/47545 (1999-09-01), None
patent: WO 00/11021 (2000-03-01), None
patent: WO 01/85664 (2001-11-01), None
Jones, S et al, The EMBO Journal vol. 12(6), pp. 2477-2482, 1993, The lux autoinducer regulates the production of exoenzyme virulence determinants inErwinia carotovoraandPseudomonas aeruginosa.
Bassler et al, Mol. Microbiology, vol. 13(2) 1994, pp. 273-286.
Jones et al, reference of record.
Coulthurst, SJ et al, Molecular Plant Pathology, 2006, vol. 7(1), pp. 31-45, Genetic and proteomic analysis of the role of luxS in the enteric phytopathogenErwinia carotovora.
Ohtani, Kaori et al, Molecular Microbiology, vol. 22(1), pp. 171-179, 2002, The luxS gene is involved in cell-cell signalling for toxin production inClostridium perfringens.
Winzer, K et al, Microbiology, 2002, vol. 148, pp. 909-922, LuxS: its role in central metabolism and the in vitro synthesis of 4-hydroxy-5-methyl-3(2H) furanone.
Henke, Jennifer M et al, Bacterial social engagement, Trends in Cell Biology, vol. 14(11), Nov. 2004, pp. 648-656.
Wei, Jun-Rong et al, International Journal of Medical Microbiology, vol. 296, pp. 117-124, 2006, N-Acylhomoserine lactone dependent cell to cell communication and social behavior in the genusSerratia.
Alm, RA et al, Nature, vol. 397, Jan. 14, 1999, pp. 176-180 and p. 719, Genomic sequence comparison of two unrealted isolates of the human gastric pathogenHelicobacter pylori.
Surette, MG et al, PNAS, USA, vol. 95, pp. 7046-7050, Jun. 1998, Quorum sensing inEscherichia coliandSalmonella typhimurium.
Surette, Michael G et al, PNAS (USA), Feb. 1999, vol. 96, pp. 1639-1644, Quarum sensing inEscherichia coli, Salmonella typhimuriumandVibrio harveyi: A new family of genes responsible for autoinducer production.
Nitzan, Y et al, Photochemistry and Photobiology, Apr. 1999, Photoinactivation ofDeinococcus radiodurans: An unusual gram positive microorganism. (abstract only).
Wei, Jun-Rong et al, International Journal of Medical Microbiology, vol. 296, pp. 117-124, N-acylhomoserine lactone-dependent cell to cell communicaiton and social behavior in the genusSerratia.
Henke, Jennifer M et al, Trends in Cell Biology, vol. 14(11), pp. 648-656, Bacterial social engagements.
Brint, J. Mark et al., “Synthesis of Multiple Exoproducts inPseudomonas aeruginosaIs under the Control of RhlR-Rhll, Another Set of Regulators in Strain PAO1 with Homology to the Autoinducer-Responsive LuxR-Luxl Family,” Journal of Bacteriology, Dec. 1999, pp. 7155-7163.
International Search Report for International Application No. PCT/US99/28751, dated Mar. 14, 2000.
Ochsner, Urs A. et al., “Autoinducer-mediated regulation of rhamnolipid biosurfactant synthesis inPseudomonas aeruginosa,” Proc. Natl. Acad. Sci. USA, vol. 92, Jul. 1995, pp. 6424-6428.
Ahmer et al., “Salmonella typhimuriumEncodes an SdiA Homolog, a Putative Quorum Sensor of the LuxR Family, That Regulates Genes on the Virulence Plasmid”Journal of Bacteriology, pp. 1185-1193 (Mar. 1998).
Allart et al., “The catalytic mechanism of adenosylhomocysteine/methylthioadenosine nucleosidase fromEscherichia coli: Chemical evidence for a transition state with a substantial oxocarbenium character”Eur. J. Biochem., 256, pp. 155-162 (1998).
Baines et al., “Purification of Immunoglobulin G (IgG)”Methods in Molecular Biology, vol. 10: Immunochemical Protocols, Ed: M. Manson (1992).
Bassler et al. “Intercellular Communication in Marine Vibrio Species: Density-Dependent Regulation of the Expression of Bioluminescence”Two-Component Signal Transduction, pp. 431-445 (1995).
Bassler et al. “Intercellular signaling inVibrio harveyi: sequence and function of genes regulating expression of luminescence”Molecular Microbiology, 9(4) 773-786 (1993).
Bassler et al., “A Multichannel Two-Component Signaling Relay Controls Quorum Sensing inVibrio harveyi” Cell-Cell Signaling in Bacteria, pp. 259-273 (1999).
Bassler et al., “Cross-Species Induction of Luminescence in the Qurorum-Sensing BacteriumVibrio harveyi”, Journal of Bacteriology, vol. 179, No. 12, pp. 4043-4045 (Jun. 1997).
Bassler, “How bacteria talk to each other: regulation of gene expression by quorum sensing”Current Opinion in Microbiology, 2:582-587 (1999).
Bassler, Bonnie L., Current Opinion in Microbiology, vol. 2, pp. 582-587, 1999.
Bassler, et al., Molecular Microbiology, 12(2):273-286.
Bassler, et al., Molecular Microbiology, vol. 9(4), pp. 773-786, 1993.
Becker et al. (1997) “Evidence for Interspecies Communication and its Potential Role in Pathogen Suppression in a Naturally Occurring Disease Suppressive Soil”,Canadian Journal of Microbiology, 43:985-990.
Bitter et al. “Expression and Secretion Vectors for Yeast”Methods in Enzymology, vol. 153, pp. 516-544 (1987).
Bitter, “Heterologous Gene Expression in Yeast”Methods in Enzymology, vol. 152, pp. 673-684 (1987).
Blattner et al. “The Complete Genome Sequence ofEscherichia coliK-12”Science, vol. 277, pp. 1453-1462 (1997).
Blattner, et al., Science vol. 277, vol. 5331, Sep. 1997, pp. 1453-1474, 1997.
Brückner et al. “Regulation of the inducible chloramphenicol acetyltransferase gene of theStaphylococcus aureusplasmid pUB112”The EMBO Journal, vol. 4 No. 9, pp. 2295-2300 (1985).
Caetano-Annollés, “Amplifying DNA with Arbitrary Oligonucleotide Primers”PCR Methods and Applications, 3:85-94 (1993).
Cheung et al. “Diminished Virulence of a sar-lagr-Mutant ofStaphylooccus aureusin the Rabbit Model of Endocarditis”The Journal of Clinical Investigation, Inc., vol. 94, pp. 1815-1822 (1994).
Conner et al. “Detection of sickle cell βs-globin allele by hybridization with synthetic oligonucleotides”Proc. Natl. Acad. Sci. USA, vol. 80, pp. 278-282 (Jan. 1983).
Cornell and Riscoe, “Cloning and expression ofEscherichia coli5′-methylthioadenosine/S-adenosylhomocysteine nucleosidase Identification of

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Compositions and methods for regulating bacterial pathogenesis does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Compositions and methods for regulating bacterial pathogenesis, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Compositions and methods for regulating bacterial pathogenesis will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-2765796

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.