Compositions and methods for producing vasodilation and antioxyt

Details Compositions and methods for producing vasodilation and antioxyt Compositions and methods for producing vasodilation and antioxyt

1986-04-18

1987-08-04

Brown, Johnnie R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

A61K 3702

Patent

active

046846220

ABSTRACT:
Vasopressin derivatives having V.sub.1 and oxytocin antagonist activity whose structures are characterized by a Mpa unit at position 1 and a des-Pro unit at position 7 are prepared by standard peptide synthetic methods also using an oxidative cyclization of a dimercaptan. Representative species are [1-deaminopenicillamine-2-(O-methyl)-tyrosine-7-desproline-8-arginine-9-de sglycine]vasopressin or [1-.beta.-mercaptopropionic acid-2-D-(O-ethyl)tyrosine-3-isoleucine-4-threonine-7-desproline-8-arginin e-9-desglycine]-vasopressin.

REFERENCES:
patent: 3941763 (1976-03-01), Sarantakis
patent: 4599324 (1986-07-01), Ali et al.
Rudinger, Peptide Hormones, Parsons (ed.), U. Park Press, Baltimore, 1976, pp. 1-7.

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