Compositions and methods for inhibiting G2 cell cycle arrest...

Details Compositions and methods for inhibiting G2 cell cycle arrest... Compositions and methods for inhibiting G2 cell cycle arrest...

2004-10-15

2010-12-14

Bristol, Lynn (Department: 1643)

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

8 to 10 amino acid residues in defined sequence

Reexamination Certificate

active

07851592

ABSTRACT:
The invention provides compositions and methods for inhibiting Chk1 and/or Chk2 kinases. Also provided are compositions and methods for inhibiting G2 cell arrest checkpoint, particularly in mammalian, e.g., human, cells. The compositions and methods of the invention are also used to treat disorders of cell growth, such as cancer. In particular, the invention provides methods for selectively sensitizing G1 checkpoint impaired cancer cells to DNA damaging agents and treatments. Also provided are methods for screening for compounds able to interact with, e.g., inhibit, enzymes involved in the G2 cell cycle arrest checkpoint, such as Chk1 and/or Chk2/Cds1 kinase.

REFERENCES:
Pommier et al. (Curr. Pharm. Design 11(22): 2855-2872 (2005).
Skolnick et al (Trends in Biotechnology, 18(1):34-39, 2000).
Vile et al (Gene Therapy, vol. 7, pp. 2-8, 2000.
Rochlitz C. F. (Swiss Medicine Weekly, 131:4-9, 2001).
Glick (Gen. Engineer. News 28(7) pp. 6 and 9 (Apr. 1, 2008)).
Verma (Nature, vol. 389, pp. 239-242, 1997).

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