Compositions and methods for increasing telomerase activity

Details Compositions and methods for increasing telomerase activity Compositions and methods for increasing telomerase activity

2004-06-23

2010-12-07

Peselev, Elli (Department: 1623)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

C514S169000

Reexamination Certificate

active

07846904

ABSTRACT:
The present invention relates to methods for increasing telomerase activity in cells. Such compositions include pharmaceutical, including topical, and nutraceutical formulations. The method and compositions are useful for treating diseases subject to treatment by an increase in telomerase activity in cells or tissue of a patient, such as, for example, HIV infection, various degenerative diseases, and acute or chronic skin aliments. They are also useful for enhancing replicative capacity of cells in culture, as in ex vivo cell therapy and proliferation of stem cells.

REFERENCES:
patent: 5629154 (1997-05-01), Kim et al.
patent: 5663160 (1997-09-01), Meybeck et al.
patent: 5770578 (1998-06-01), Binder et al.
patent: 5785977 (1998-07-01), Breithbarth
patent: 5786343 (1998-07-01), Ber
patent: 5916565 (1999-06-01), Rose et al.
patent: 5942233 (1999-08-01), Chang
patent: 6007989 (1999-12-01), West et al.
patent: 6126942 (2000-10-01), Yang
patent: 6153208 (2000-11-01), McAtee et al.
patent: 6162459 (2000-12-01), Hu
patent: 6171604 (2001-01-01), Mousa
patent: 6190678 (2001-02-01), Hasenoehrl et al.
patent: 6277396 (2001-08-01), Dente
patent: 6346539 (2002-02-01), Raman et al.
patent: 6696094 (2004-02-01), Wu
patent: 6855344 (2005-02-01), Chou
patent: 2002/0044977 (2002-04-01), Close
patent: 2002/0164387 (2002-11-01), Wei et al.
patent: 2002/0182272 (2002-12-01), Halstead
patent: 2003/0108629 (2003-06-01), Chou
patent: 2007/0042962 (2007-02-01), Adams
patent: 2007/0122501 (2007-05-01), Harley et al.
patent: 2007/0154435 (2007-07-01), Harley
patent: 1283462 (2001-02-01), None
patent: 1079265 (2002-02-01), None
patent: 1383853 (2002-12-01), None
patent: 1406585 (2003-04-01), None
patent: 62-012791 (1987-01-01), None
patent: WO 99/35243 (1999-07-01), None
patent: WO 00/08135 (2000-02-01), None
patent: WO 00/31238 (2000-06-01), None
patent: WO 01/01996 (2001-01-01), None
patent: WO 02/091999 (2002-11-01), None
patent: WO 02/91999 (2002-11-01), None
patent: WO 2005/000245 (2005-01-01), None
patent: WO 2005/000248 (2005-01-01), None
patent: WO 2005/044179 (2005-05-01), None
“Astragalus” www.drugs.com
pp/astragalus.html, 5 pages (Oct. 20, 2008).
Bedir, E. et al., “Cycloartane triterpene glycosides from the roots ofAstragalus brachypterusandAstragalus microcephalus,” J. Nat. Prod., 61:1469-72 (1998).
Chu, D-T. et al., “Fractionated extract ofAstragalus membranaceus, a Chinese medicinal herb, potentiates lak cell cytotoxicity generated by a low dose of recombinant interleukin-2,”J. Clin. Lab. Immunol., 26:183-7 (1988).
Chu, D-T. et al., “Immunotherapy with Chinese medicinal herbs. II Reversal of cyclophosphamide-induced immune suppression by administration of fractionated Astragalus membranaceus in vivo,”J. Clin. Lab. Immunol., 25:125-9 (1988).
Ionkova, I., “Astragalusspecies (Milk Vetch): in Vitro culture and the production of saponins, astragaline, and other biologically active compounds,” Biotechnology in Agriculture and Forestry, vol. 33, Medicinal and Aromatic Plants VIII, Y. Bajaj, Ed., Springer Verlag, Berlin, pp. 97-138 (1995).
Juntao, L. et al., “Effect of retinoic acid and genseng on the telomerase activity in the liver cancer cell,”J. Trop. Med., 2(1):39-40 (2002) (English Abstract).
Xiao, H. et al., “Total analytical method for RadixAstragaliextract using two-binary multisegment gradient elution liquid chromatography,”J. Sep. Sci., 24:186-96 (2001).
Zhao, K. et al., “Enhancement of the immune response in mice by Astragalus membranaceus extracts,”Immunopharmacology, 20:225-34 (1990).
Zheng, Z. et al., “Studies on chemical constituents and immunological function activity of hairy root ofAstragalus membranaceus,” Chinese Journal of Biotechnology, 14(2):L93-7 (1998).
Bedir, E. et al., “Immunostimulatory effects of cycloartane-type triterpene glycosides fromAstragalusspecies”,Biol. Pharm. Bull., 23(7):834-837 (2000).
Bodnar, A. G. et al., “Extension of life-span by introduction of telomerase into normal human cells”Science, 279(5349):349-52 (1998).
Calzada, L. et al., “Effect of tetracyclic triterpenes (argentatins A, B and D) on the estradiol receptor of hormone-dependent tumors of human breast”,Medical Science Research, 23(12):815-16 (1995).
Chiu, C. P. et al., “Replicative senescence and cell immortality: the role of telomeres and telomerase”,Proc. Soc. Exp. Biol. Med., 214(2):99-106 (Feb. 1997).
Dagarag, M. et al., “Differential impairment of lytic and cytokine functions in senescent human immunodeficiency virus type 1-specific cytotox T lymphocytes”,Journal of Virology, 77(5):3077-83 (2003).
Farwell, D. G. et al., “Genetic and epigenetic changes in human epithelial cells immortalized by telomerase”,American Journal of Pathology, 156(5):1537-47 (2000).
Fujimoto, R. et al., “Expression of telomerase components in oral keratinocytes and squamous cell carcinomas”,Oral Oncology, 37(2):132-40 (2001).
Funk, Walter D. et al., “Telomerase expression restores dermal integrity to in vitro- aged fibroblasts in a reconstituted skin model”,Experimental Cell Research, 258(2):270-278 (2000).
Harle-Bachor, C. et al., “Telomerase activity in the regenerative basal layer of the epidermis inhuman skin and in immortal and carcinoma-derived skin keratinocytes”,Proc. Natl. Acad. Sci. USA, 93(13):6476-81 (1996).
Harley, C. B. et al., “Telomeres shorten during ageing of human fibroblasts”,Nature, 345(6274):458-60 (1990).
Henderson, S. et al., “In situ analysis of changes in telomere size during replicative aging and cell transformation”,Journal of Cell Biology, 134(1):1-12 (1996).
Huang, Y. et al., “Selected non-timber forest products with medicinal applications from Jilin Province in China”, Conference Title: Forest communities in the third millennium: Linking research, business, and policy toward a sustainable non-timber forest product sector; Kenora, Ontario, Canada, Oct. 1-4, 1999; General Technical Report- North Central Research Station, USDA Forest Service (No. NC-217): p. 93-101 (2000).
International Search Report for PCT application PCT/US2004/0202777 search report dated Mar. 21, 2005, 2 pages (2005).
Kaneko, M. et al., “Accelerated recovery from cyclophosphamide-induced leukopenia in mice administered a Japanese ethical herbal drug,Hochu-ekkito”, Immunopharmacology, 44(3):223-231 (1999).
Kang, M. K. et al., “Replicative senescence of normal human oral keratinocytes is associated with the loss of telomerase activity without shortening of telomeres”,Cell Growth&Differentiation, 9(1):85-95 (1998).
Khushbaktova, Z. A. et al.,“Influence of cycloartanes from plants of the genusAstragalusand their synthetic analogs on the contractive function of themyocarbiumand the activity of Na, K-ATPase”,Chemistry of Natural Compounds, 30(4):469-473 (1994).
Kitagawa et al., Saponin and Sapogenol XXXIV. Chemical Constituents of Astragali Radix, the Root ofAstragalus membranaceusBunge (1). Cycloastragenol, the 9,19-Cyclolanostane-type Aglycone of Astragalosides, and the Artifact Aglycone Astragenol,Chem. Pharm. Bull., 31(2):689-697 (1983).
Kitagawa et al., Saponin and Sapogenol XXXV. Chemical Constituents of Astragali Radix, the Root ofAstragalus membranaceusBunge (2). Astragalosides I, ll and IV, Acetylastragaloside I and Isoastragalosides I and II,Chem. Pharm. Bull., 31(2):698-708 (1983).
Kinjo, J. et al., “Anti-herpes virus activity of fabaceous triterpenoidal saponins”,Biological&Pharmaceutical Bulletin 23(7):887-9 (2000).
Lee, K. M. et al., “Immortalization with telomerase of the Nestin-positive cells of the human pancreas”,Biochem Biophys Res Commun, 301(4):1038-44 (2003).
Mattson, M. P. ,“Emerging neuroprotective strategies for Alzheimer's disease: dietary restriction, telomerase activation, and stem cell therapy”,Experimental Gero

Affiliated with

Also associated with

Rating

Compositions and methods for increasing telomerase activity does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Compositions and methods for increasing telomerase activity, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Compositions and methods for increasing telomerase activity will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4199686