Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Oxidoreductase
Reexamination Certificate
2005-04-26
2005-04-26
Nashed, Nashaat T. (Department: 1652)
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
Oxidoreductase
C435S252100, C435S252300, C435S252350, C536S023200
Reexamination Certificate
active
06884608
ABSTRACT:
Isolated nucleic acid sequences and polypeptides encoded thereby for epothilone B hydroxylase and mutants and variants thereof and a ferredoxin located downstream from the epothilone B hydroxylase gene are provided. Also provided are vectors and cells containing these vectors. In addition, methods for producing recombinant microorganisms, methods for using these recombinant microorganism to produce hydroxyalkyl-bearing epothilones and an epothilone analog produced by a mutant of epothilone B hydroxylase are provided.
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Basch Jonathan David
Chiang Shu-Jen David
Liu Suo-Win
Nayeem Akbar
Sun Yuhua
Bristol--Myers Squibb Company
Golian Paul D.
Klein Christopher A.
Nashed Nashaat T.
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