Composition comprising interleukin-2 and thymidine kinase for th

Details Composition comprising interleukin-2 and thymidine kinase for th Composition comprising interleukin-2 and thymidine kinase for th

1997-07-16

2000-07-18

Crouch, Deborah

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Genetically modified micro-organism, cell, or virus

424 9321, 514 44, A61K 4800

Patent

active

060903783

ABSTRACT:
Composition for use in the treatment of tumors and the immunization of humans or animals comprising a synergistic association of cells, viruses, or bacteria expressing, transitorily, in organisms at least one gene for producing in vivo one or more immunomodulators, and viruses, or cells producing viruses, said viruses preferably infecting dividing cells of the treated organisms and carrying within their genome at least one gene whose expression in the dividing cells will cause their destruction.

REFERENCES:
patent: 5529774 (1996-06-01), Barba et al.
Hodgson, Exp. Opin. Ther. Pat., 1992 5(5), 459-468.
Culver et al., TIG, 10(5), 1994, 174-178.
Miller et al., FASEB Journal, 9, 1995, 190-199.
Marshall, Science, 269, 1995, 1050-1055.
Plaskin et al., Int. J. Cancer, 52, 1992, 771-777.
Marshall et al. (1995) Science, 269, 1050-1055.
Culver et al. (1994) TIG, 10 (5), 174-178.
Hodgson et al. (1995) Exp. Opin. Ther. Pat., 5 (5), 459-468.
Miller et al. (1995) FASEB, 9, 190-199.

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