Drug – bio-affecting and body treating compositions – Lymphokine – Interleukin
Patent
1989-06-15
1993-02-16
Russel, Jeffrey E.
Drug, bio-affecting and body treating compositions
Lymphokine
Interleukin
514 12, 530350, 530351, A61K 3702, C07K 1300
Patent
active
051869314
ABSTRACT:
A composition and a method for supporting bone marrow transplantation are disclosed. The composition comprises a therapeutically acceptable amount of human B cell differentiation factor, or its biological equivalent, optionally in combination with an auxiliary agent selected from IL-1, IL-3, IL-4, IL-5, G-CSF, GM-CSF, and M-CSF. The composition also promotes the proliferation of hematopoietic cells in vitro.
REFERENCES:
patent: 4730036 (1988-03-01), Ralph et al.
patent: 4808611 (1989-02-01), Cosman
patent: 4810643 (1989-03-01), Souza
patent: 4965195 (1990-10-01), Namen et al.
Watson et al, "Molecular Cloning of the Polypeptide Factors that Stimulate Growth, Maturation, and Function of Blood Cells", Molecular Biology of the Gene, vol. II, pp. 983-987 (4th ed. 1987).
Kolata, "Clinical Promise with New Hormones", Science, vol. 236, May 1, 1987, pp. 517-519.
Clark et al. "The Human Hematopoietic Colony-Stimulating Factors", Science, vol. 236, Jun. 5, 1987, pp. 1229-1237.
Hildeman, Essentials of Immunology, Elsevier, 1984, Title pg., Preface pg.
Oppenheim et al., Immunophysiology, Oxford U. Press 1990, Title pg., pp. IX, X, XI, 88, 98, 99, 101, 102.
Hirano, et al., Nature, vol. 324, Nov. 6, 1986, pp. 73 to 76.
G. G. Wong et al., The Journal of Immunology vol. 140, No. 9 (May 1, 1988) pp. 3040-3044 "Stimulation of murine hemopoietic colony formation . . . ".
T. Masaoka et al., Bone Marrow Transplantation, vol. 3 (Mar. 1988) pp. 121-127 "Administration of human urinary colony stimulating factor . . . ".
Ikebuchi et al, "Interleukin 6 enhancement of interleukin 3-dependent proliferation of multipotential hemopoietic progenitors." Proc. Natl. Acad, Sci. USA, vol. 84, pp. 9035-9039, Dec. 1987.
Koike et al, "Synergism of BSF-2/Interleukin 6 and Interleukin 3 on Development of Multipotential Hemopoietic Progenitors . . . ". J. Exp. Med., vol. 168, pp. 879-890, Sep. 1988.
Laytor et al, "T Cell-Derived B Cell Growth (BCGF) and Differentiation (BCDF) Factors: Suppression of the Activity of BCDF . . . ". J. Immunol., vol. 130(6), pp. 2502-2504, 1983.
Nakagawa et al, "Demonstration That Human B Cells Respond Differently to IL-2 and BCDF based on their stage of Maturation." J. Immunol., vol. 137(10), pp. 3175-3182, Nov. 15, 1986.
Akiyama Yukio
Hirano Toshio
Kishimoto Tadamitsu
Matsui Hiroshi
Okano Akira
Ajinomoto Co. Inc.
Kishimoto Tadamitsu
Russel Jeffrey E.
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