Composition and method containing optically pure (S) metoprolol

Details Composition and method containing optically pure (S) metoprolol Composition and method containing optically pure (S) metoprolol

1992-11-16

1994-11-08

Cintins, Marianne M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Nitrogen containing other than solely as a nitrogen in an...

514821, 514929, A61K 31135

Patent

active

053627571

ABSTRACT:
Optically pure (S) metoprolol, which is substantially free of the (R) enantiomer, is a potent beta-blocker for treating myocardial infarction and for relieving the symptoms of angina pectoris, cardiac arrhythmia and hypertension in individuals. A method is disclosed utilizing the optically pure (S) configurational enantiomer of metoprolol for treating cardiovascular disorders while reducing undesirable side effects associated with the administration of beta-blockers.

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L. Bradley and S. A. Doggrell, Arch. Int. Pharmacodyn. 270:61-78 (1984).
CA 112(17):151274z, Wahlund et al., 1990.

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