Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2008-04-08
2008-04-08
Bernhardt, Emily (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C544S362000, C544S357000, C544S295000, C544S215000, C544S238000, C514S241000, C514S252020, C514S252110, C514S252180
Reexamination Certificate
active
07354924
ABSTRACT:
This invention provides Compounds I having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the invention is concerned with azaindoleoxoacetyl piperazine derivatives. These compounds possess unique antiviral activity, whether used alone or in combination with other antivirals, antiinfectives, immunomodulators or HIV entry inhibitors. More particularly, the present invention relates to the treatment of HIV and AIDS. Compound I iswherein:Q is selected from the group consisting of:m is 1 or 2;—W— isA is selected from the group consisting of C1-6alkoxy, aryl and heteroaryl; in which said aryl is phenyl or napthyl; said heteroaryl is selected from the group consisting of pyridinyl, pyrimidinyl, pyrazinyl, triazinyl, furanyl, thienyl, pyrrolyl, imidazolyl, thiazolyl, isothiazolyl, oxazolyl, isoxazolyl, quinolinyl, isoquinolinyl, benzofuranyl, benzothienyl, benzoimidazolyl and benzothiazolyl; and said aryl or heteroaryl is optionally substituted with one or two of the same or different members selected from the group consisting of amino, nitro, cyano, hydroxy, C1-6alkoxy, —C(O)NH2; and C1-6alkyl, —NHC(O)CH3, halogen and trifluoromethyl.
REFERENCES:
patent: 5023265 (1991-06-01), Scherlock et al.
patent: 5124327 (1992-06-01), Greenlee et al.
patent: 5424329 (1995-06-01), Boschelli et al.
patent: 6476034 (2002-11-01), Wang et al.
patent: 2002/0061892 (2002-05-01), Wang et al.
patent: 2003/0069266 (2003-04-01), Wang et al.
patent: 2004/0162298 (2004-08-01), Ho et al.
patent: 0530907 (1993-03-01), None
patent: WO 93/01181 (1993-01-01), None
patent: WO 95/04742 (1995-02-01), None
patent: WO 96/11929 (1996-04-01), None
patent: WO 00/71535 (2000-11-01), None
patent: WO 00/76521 (2000-12-01), None
patent: WO 01/62255 (2001-08-01), None
patent: 03/072028 (2003-09-01), None
Drug Evaluations by American medical Association (6thEd.) p. 1615-1627 (1986).
M. Font, et al, “Indoles and Pyridazino[4,5-b]Indoles as Nonnucleoside Analog Inhibitors of HIV-1 Reverse Transcriptase,” Eur. J. Med. Chem., 30, pp. 963-971, 1995.
D. L. Romero, et al, J. Med. Chem., 36, pp. 1505-1508, 1993.
S. D. Young, et al, “2-Heterocyclic Indole-3-Sulfones as Inhibitors of HIV-1 Reverse Transcriptase,” Bioorganic & Medicinal Chemistry Letters, 5(5), pp. 491-496, 1995.
M. J. Genin, et al, “Synthesis and Bioactivity of Novel Bis(Heteroaryl)Piperazine (BHAP) Reverse Transcriptase Inhibitors: Structure-Activity Relationships and Increased Metabolic Stability of Novel Substituted Pyridine Analogs,” J. Med. Chem., 39, pp. 5267-5275, 1996.
R. Silvestri, et al, Antiviral Chemistry & Chemotherapy, 9, pp. 139-148, 1998.
A. Fredenhagen, et al, “Semicochliodinol A and B: Inhibitors of HIV-1 Protease and EGF-R Protein Tyrosine Kinase Related to Asterriquinones Produced by the FungusChrysosporium Merdarium,” Journal of Antibiotics, 50(5), pp. 395-401, 1997.
M. Kato, et al, “New 5-HT3(Serotonin-3) Receptor Antagonists. IV. Synthesis and Structure-Activity Relationships of Azabicycloalkaneacetamide Derivatives,” Chem. Pharm. Bull., 43(8), pp. 1351-1357, 1995.
V. Levacher, et al, “Broadening in the Scope of NADH Models by Using Chiral and Non-Chiral Pyrrolo [2,3-b]Pyridine Derivatives,” TETRAHEDRON, 47(3), pp. 429-440, 1991.
Kadow John F.
Matiskella John D.
Meanwell Nicholas A.
Regueiro-Ren Alicia
Ueda Yasutsugu
Bernhardt Emily
Bristol--Myers Squibb Company
Chapman Jennifer C.
DuBoff Samuel J.
Levis John F.
LandOfFree
Composition and antiviral activity of substituted... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Composition and antiviral activity of substituted..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Composition and antiviral activity of substituted... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2761181