Complementary adenoviral systems and cell lines

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing compound containing saccharide radical

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4353201, 435325, 435366, 536 242, C12P 1934, C12N 1511, C12N 516, C12N 522

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058518061

ABSTRACT:
The present invention provides multiply replication deficient adenoviral vectors having a spacer in at least one replication deficient adenoviral region, as well as complementing cell lines therefor. Also provided are means of constructing the multiply replication deficient adenoviral vectors and methods of use thereof, e.g., in gene therapy.

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