Chemistry: molecular biology and microbiology – Spore forming or isolating process
Patent
1987-09-04
1991-04-02
Kepplinger, Esther L.
Chemistry: molecular biology and microbiology
Spore forming or isolating process
435 7021, 4351722, 435948, 424 858, 424 86, 424 87, 424430, 530387, 530388, 530808, 530809, 935110, C12N 500, A61K 3900
Patent
active
050046942
ABSTRACT:
Novel monoclonal antibodies specific to Trichomonas vaginalis, having complement--fixing ability and lysing Trichomonas vaginalis in the presence of complement are disclosed and may be used in therapy and diagnosis of trichomoniasis. Hybridomas producing and compositions comprising these antibodies are also disclosed.
REFERENCES:
Cooper, N., "The Complement System" in Basic & Clinical Immunology, 3rd ed., H. H. Fudenberg editor, pp. 83-95 (1980).
Biological Abstract 68(10): 60895.
Biological Abstract 64(11) 62897.
Torian et al., "Specific and Common Antigens of Trichomonas vaginalis Detected by Monoclonal Antibodies," Infection and Immunity, Jan. 1984, vol. 43, No. 1, pp. 270-275.
Connelly et al., "Identification of a Surface Antigen of Trichomonas vaginalis," Infection and Immunity, Aug. 1985, vol. 49, No. 2, pp. 270-274.
Alderete et al., "Monoclonal Antibody to a Major Surface Glycoprotein Immunogen Differentiates Isolates and Subpopulations of Trichomonas vaginalis," Infection and Immunity, Apr. 1986, vol. 52, No. 1, pp. 70-75.
Alderete et al., "Monoclonal Antibody to a Major Glycoprotein Immunogen Mediates Differential Complement-Independent Lysis of Trichomonas vaginalis," Infection and Immunity, Sep. 1986, pp. 697-699, vol. 53, No. 3.
Alderete, J., "Antigen Analysis of Several Pathogenic Strains of Trichomonas vaginalis," Infection and Immunity, Mar. 1983, pp. 1041-1047, vol. 39, No. 3.
Chang et al., "Monoclonal Antibodies Against Trichomonas vaginalis," Hybridoma, vol. 5, No. 1, 1986, pp. 43-51.
Hardy, R., "Complement Fixation by Monoclonal Antibody-Antigen Complexes," in Handbrook of Experimental Immunology, vol. 1, 4th edition, 1986, pp. 40.1-40.12.
Goding, J., Monoclonal Antibodies, Principles and Practice, 2nd edition, 1986, pp. 11-17 and 47-48 and 86-87.
Draghi Enrica
Moay Neomi
Interpharm Laboratories Ltd.
Kepplinger Esther L.
Spiegel Carol A.
Williams Stephan P.
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