Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1995-06-07
1998-01-13
Datlow, Philip I.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514331, 546190, 546191, 546229, 546234, A61K 31445, C07D21108, C07D21136
Patent
active
057080062
ABSTRACT:
The invention relates to new compounds of general formula I ##STR1## and the pharmaceutically acceptable salts thereof, wherein A, B, Z, R.sup.1, R.sup.2, R.sup.3 and m are defined as in the specification, processes for preparing them and pharmaceutical compositions containing these compounds. The compounds are valuable neurokinin (tachykinin) antagonists.
REFERENCES:
patent: 3518274 (1970-06-01), Strycker
patent: 3862946 (1975-01-01), Havera
patent: 3906100 (1975-09-01), Havera
Advani et al., "N-.beta.-Styrylamidines--A Novel Class of Compounds from an Anomalous Bischler-Napieralski Reaction", Tetrahedron Letters, 56, pp. 5825-5828 (1968).
Nagarajan, Chemical Abstract, vol. 117, No. 11, p. 823 Abstract No. 111219g (1992).
Briem Hans
Dollinger Horst
Jung Birgit
Schnorrenberg Gerd
Speck Georg
Boehringer Ingelheim KG
Datlow Philip I.
Devlin Mary-Ellen
Raymond Robert P.
Stempel Alan R.
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