Combinations of enzyme inhibitors and the use thereof

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

Reexamination Certificate

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C514S019300, C514S114000, C514S119000, C514S317000, C514S326000, C514S330000, C514S365000, C514S400000, C514S422000, C514S423000, C514S576000, C514S578000, C514S579000, C514S665000

Reexamination Certificate

active

10250476

ABSTRACT:
Combination of inhibitors of dipeptidyl peptidase IV (DP IV) and enzymes having the same substrate specificity (DP IV-analogous enzymatic activity) and inhibitors of alanyl aminopeptidase (aminopeptidase N, APN) and of enzymes having the same substrate specificity (APN-analogous enzymatic activity) for a more than additive to superadditive inhibition for the treatment of arteriosclerosis, for the treatment of allergic reactions of the type I according to the Gell and Coombs classification and for the treatment of dermatological diseases with follicular and epidermal hyperkeratoses and an enhanced proliferation of keratinocytes.

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