Collagen-binding proteins from enterococcal bacteria

Details Collagen-binding proteins from enterococcal bacteria Collagen-binding proteins from enterococcal bacteria

2005-04-11

2009-12-29

Ford, Vanessa L. (Department: 1645)

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

C424S190100, C424S184100, C536S023100, C536S023700

Reexamination Certificate

active

07638135

ABSTRACT:
A collagen-binding MSCRAMM entitled Ace from enterococcal bacteria is provided which was homologous to the ligand-binding region of Cna, the collagen-binding MSCRAMM fromStaphylococcus aureus, and which can be utilized to inhibit adhesion of enterococcal bacteria to extracellular matrix proteins. The N-terminal region of Ace contained a region (residues 174-319), or A domain, contains several 47-residue tandem repeat units between the collagen-binding site and cell wall-associated regions. The Ace protein can be utilized in methods of preventing and/or treating enterococcal infection, and in addition, antibodies raised against Ace, or its A domain, can be used to effectively inhibit the adhesion of enterococcal cells to a collagen substrate.

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Patti et al., “Critical Residues in the Ligand-binding Site of theStaphylococcus aureusCollagen-binding Adhesin (MSCRAMM)”, The Journal of Biological Chemistry, vol. 270, No. 20, May 19, 1995, pp. 12005-12011.

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