Colchicine and thiocolchicine derivatives with antiinflammatory

Organic compounds -- part of the class 532-570 series – Organic compounds – Amino nitrogen containing

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514630, C07C23300, A01N 3718

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active

059732040

ABSTRACT:
The present invention relates to 3-demethyl-thiocolchicine derivatives of general formula (I) ##STR1## in which R can be ##STR2## to a process for the preparation thereof, to pharmaceutical compositions containing them and to the use thereof for the preparation of medicaments with muscle relaxant and antiinflammatory activities.

REFERENCES:
patent: 2820029 (1958-01-01), Muller et al.
Grant & Hackh's Chemical Dictionary, 5th Edition, col. 1, p. 113, Feb. 24, 1988.
Kerekes et al., "Synthesis and Biological Effects of Novel Thiocochicines"; J. Med. Chem., vol. 28, No. 9, 1985, pp. 1204-1208, XP002069840.

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